Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis  

作　　者：YAO San Qiao HE Qin Cheng YUAN Ju Xiang CHEN Jie CHEN Gang LU Yao BAI Yu Ping ZHANG Chun Min YUAN Yang XU Ying Jun 

机构地区：[1]Department of Occupational and Environmental Health, School of Public Health, Hebei Union University [2]Division of Pneumoconiosis, School of Public Health, China Medical University [3]Department of Pneumoconiosis, Beidaihe Sanitarium for China Coal Miners [4]Department of Community Medicine,Tangshan Workers’ Hospital

出　　处：《Biomedical and Environmental Sciences》2013年第11期930-933,共4页生物医学与环境科学（英文版）

基　　金：supported by the Natural Science Foundation of China (30671741);the Pneumoconiosis Treatment Foundation for China Coal Miners (2005-03);the Science and Technology Support Program of Hebei Province (09276196D)

摘　　要：The role of Fas/Fas ligand （FasL） in mediating alveolar macrophage （AM）-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied. It showed that the serum levels of IL-1β, TNF-a, IL-8, MIP-la, MCP-1, and TGF-β1 were higher in silicosis patients than in controls, and increased with the progression of silicosis except TGF-β1 and IL-8. TGF-β1, IL-8, MCP-1,The role of Fas/Fas ligand （FasL） in mediating alveolar macrophage （AM）-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied. It showed that the serum levels of IL-1β, TNF-a, IL-8, MIP-la, MCP-1, and TGF-β1 were higher in silicosis patients than in controls, and increased with the progression of silicosis except TGF-β1 and IL-8. TGF-β1, IL-8, MCP-1,

关 键 词：FASL AM 

分 类 号：R135.2[医药卫生—劳动卫生]