慢加亚急性肝衰竭患者低磷血症的发生情况  

Hypophosphatemia in patients with subacute on chronic liver failure

作　　者：刘海霞[1] 段忠辉[1] 朱跃科[1] 李娟[1] 于红卫[1] 孟庆华[1] 

机构地区：[1]首都医科大学附属北京佑安医院重症肝病科,100069

出　　处：《北京医学》2013年第12期986-988,共3页Beijing Medical Journal

基　　金：佑安肝病艾滋病基金(BJYAH-2011-078)

摘　　要：目的探讨慢加亚急性肝衰竭患者低磷血症发生的情况及其与肝功能的关系。方法97例乙肝患者分为慢性肝炎组(30例)、肝硬化组(28例)、慢加亚急性肝衰竭组(39例),检测电解质、肝功能,分析3组患者的电解质异常情况,低磷血症发生情况。结果慢性肝炎组低磷血症发生率为6.7%,肝硬化组为28.6%,慢加亚急性肝衰竭组为87.2%。3组血磷浓度分别为(1.11±0.18)mmol/L、(0.88±0.24)mmol/L、(0.46±0.28)mmol/L,差异有统计学意义(P=0.000)。在肝衰竭组,轻中度和重度低磷血症患者的肝肾功能、凝血酶原活动度比较,差异无统计学意义。结论低磷血症是慢加亚急性肝衰竭患者常见的电解质紊乱,需要密切监测血磷情况。Objective To investigate the correlative factors of hypophosphatemia in the patients with subacute on chronic liver function failure. Methods Clinical data of 97 patients were analyzed. The patients were divided into 3 groups, chronic hepatitis group （n=30）, cirrhosis group （n=28）, subacute on liver failure group （n=39）. Electrolytes and liver function were analyzed retrospectively. Results The morbidity of hypophosphatemia was 6.7% in choronic hepatitis group, 28.6% in eirrosis group, 87.2% in subaeute on chronic liver failure. The phosphate level in cirrhosis group and sub- acute on liver failure group were （0.88±0.24）, （0.46±0.28）mmo]/L respectively, which was significantly lower than that of the chronic hepatitis group [（1.11±0.18）retool/L, P = 0.000]. However, there were no significant differences in PTA, renal function and liver function between mild and severe hypophosphatemia in the subacute on liver failure group. Conclusion Hypophosphatemia is the very common kind of electrolyte disorder in subacute on liver failure. The level of serum phos- phate should be monitored.

关 键 词：慢性肝炎 肝硬化 慢加亚急性肝衰竭 低磷血症 

分 类 号：R575.3[医药卫生—消化系统]