γ干扰素释放试验在结核性胸膜炎的诊断价值  

The diagnostic value of interferon-γ release assay in tuberculous pleuritis

作　　者：崔丹[1] 赵杰[1] 杨永辉[1] 刘朋冲[1] 张红漫[1] 冯秀莉[1] 李志惠[1] 

机构地区：[1]河北省胸科医院结核一科,石家庄050041

出　　处：《北京医学》2013年第12期996-998,共3页Beijing Medical Journal

摘　　要：目的评价γ干扰素释放试验在结核性胸膜炎的诊断价值。方法采用T细胞斑点试验(T-Spot-TB)试剂盒对138例结核性胸腔积液和64例恶性胸腔积液患者的外周血和胸腔积液标本进行检测,计算斑点数和T-Spot-TB阳性率,计算其敏感性、特异性。结果结核性胸腔积液患者外周血和胸腔积液中T-Spot-TB阳性率[(84.8%(117/138)、92.0%(127/138)]显著高于恶性胸腔积液患者[25.0%(16/64)、15.6%(10/64)],差异有统计学意义(X^2=116.95,P<0.05;X^2=89,18,P<0.05)。胸腔积液γ干扰素释放试验诊断结核性胸腔积液的敏感性为92.0%,高于外周血的敏感性(84.8%)。结论外周血和胸腔积液中γ干扰素释放试验阳性均可作为诊断结核性胸腔积液的参考指标,而胸腔积液较外周血具有更重要的临床意义。Objective To analyze the diagnostic value of interferon-γ release assay in tuberculous pleural effusion. Methods The level of interferon-γ was detected by T-Spot-TB kit in 138 patients with tuberculous pleural effusion and 64 patients with malignant pleural effusion. The amount of the spots,positive rate of T-Spot-TB, sensitivity and specifity were analyzed. Results The positive rates of T-Spot-TB in pleural effusion and peripheral blood of tuberculous pleuritis were higher than those in malignant pleuritis, the difference was statistically significant（z2--116.95, P 〈 0.05; %2=89.18, P 〈 0.05）. The diagnostic sensitivity of the interferon-γ release assay of tuberculous pleural effusion was 92.0%, which was higher than that in peripheral blood（84.8%）. Conclusion The interferon-γ release assay of pleural effusion and peripheral blood could be an important reference indicator for the diagnosis of tuberculous pleural effusion, and the interferon-γ re- lease assay of pleural effusion is more important than that of peripheral blood.

关 键 词：Γ干扰素释放试验 结核性胸腔积液 恶性胸腔积液 

分 类 号：R521.7[医药卫生—内科学]