2012年江西省南昌市手足口病病原学监测结果分析  

Etiological surveillance of hand foot and mouth disease in Nanchang,Jiangxi,2012

作　　者：贺凤兰[1] 夏文[1] 周显凤[1] 樊国印[1] 龙慧[1] 龙永艳[1] 倪贤生 

机构地区：[1]南昌市疾病预防控制中心,江西南昌330038

出　　处：《疾病监测》2013年第11期905-907,共3页Disease Surveillance

摘　　要：目的分析江西省南昌市2012年临床诊断为手足口病患者标本的病原学检测结果,为手足口病的临床诊治和防控提供实验室依据。方法采用实时荧光定量反转录-聚合酶链反应(real time RT-PCR)对2012年1—12月间1028例医院诊断为手足口病的患者标本核酸进行鉴定分型,并统计分析。结果临床诊断为手足口病的患者标本1028份中,632份为肠道病毒通用阳性,总阳性率为61.48%,其中肠道病毒71型(EV71)、柯萨奇病毒A组16型(Cox A16)、EV71和Cox A16混合感染、其他肠道病毒阳性检出率分别为39.0%、10.21%、0.09%和12.16%。病原学检测阳性标本中男女性别比为1.8∶1;发病年龄段主要集中在5岁以下儿童(94.36%),尤其是3岁以下男童。结论 2012年南昌地区手足口病的主要病原体为EV71,且较2009—2011年有上升趋势。Objective To understand the etiological characteristics of hand foot and mouth disease （HFMD） in Nanchang in 2012 and provide scientific evidence for the prevention and control of HFMD. Methods From January to December 2012, a total of 1028 samples were collected from clinically diagnosed HFMD cases for detection of entericvirus with real time RT-PCR. Results Entericviruses were detected in 632 of 1028 samples （61.48%）, and 401 were positive for EV71 （39. 0% ）, 105 were positive for Cox A16 （ 10. 21% ） ; 1 was identified as co-infection with EV71 and Cox A16; 125 were positive for other unknown entericviruses （12. 16% ）. The male to female ratio of laboratory confirmed patients was 1.8： 1. HFMD mainly occurred in children aged 〈 5 years （94. 36% ）, especially in boys less than 3 years old. Conclusion The major pathogen causing HFMD was EVT1 in Nanchang in 2012, and its proportion increased compared with 2009 -2011.

关 键 词：手足口病 EV71 COX A16 流行特征 病原学监测 

分 类 号：R725.1[医药卫生—儿科] R181.3[医药卫生—临床医学]