WW结构域与Hippo信号通路  

WW Domain and the Hippo Signal Pathway

作　　者：丁鑫[1] 孟刚[1] 童晓玲[1] 代方银[1] 鲁成[1] 

机构地区：[1]家蚕基因组生物学国家重点实验室,农业部蚕桑功能基因组与生物技术重点实验室,西南大学生物技术学院,重庆400716

出　　处：《蚕业科学》2013年第6期1177-1185,共9页ACTA SERICOLOGICA SINICA

基　　金：国家高技术研究计划"863"项目(No.2013AA102507);国家自然科学基金项目(No.31072088);中央高校基本科研业务重大培育项目(No.XDJK2013A001)

摘　　要：后生动物中存在多个调控器官发育大小的信号转导通路,其中Hippo信号通路在组织器官的发育过程中形成了一个极为保守和复杂的信号调控网络。构成Hippo通路的各个蛋白质组分均包含多个结构模块,而WW结构域在该通路的核心组分、上游调控因子以及通路末端效应因子等各个层次上广泛分布。基于WW结构域及其偶联配体PPxY基序在Hippo通路中的广泛分布,将有助于研究Hippo通路在器官发育及肿瘤发生中的分子机制和发现新的通路组成成分。本文综述Hippo通路与WW结构域的关系以及在果蝇和高等动物中的研究现状,为深入解析Hippo通路在昆虫和高等动物中的作用与调控机制提供有参考价值的信息。Metazoans have several signal pathways to regulate organ development, among which Hippo signal pathway has developed into a highly conserved and complex signaling network during the development of tissues and organs. Various proteins constituting the Hippo pathway have multiple structural modules, among which WW domain is widely distributed in core components, upstream regulatory factors, and terminal effectors of the Hippo pathway. Enrichment of WW domain and its cognate ligand PPxY motif in the Hippo pathway provides a versatile platform to understand the molecular mechanisms used by Hippo pathway in the regulation of organ development and tumorogenesis, and to unveil new pathway components as well. This review focuses on the relationship between Hippo pathway and WW domain and the current status of related researches in Drosophila and higher animals, which would be beneficial for further researches on functionin.cl and regulatory mechanisms of Hippo pathway in insects and higher animals.

关 键 词：Hippo信号通路 WW结构域 PPxY基序 

分 类 号：Q75[生物学—分子生物学]