TLR9基因rs 187084位点多态性与子宫内膜异位症的相关性研究  

Association between susceptibility of endometriosis and single nucleotide polymorphisms of toll-like receptors(TLRs) 9 rs187084

作　　者：吴林珍[1] 胡志英[1] 赵剑虹[1] 孙亚青 王晏鹏[2] 

机构地区：[1]杭州市红十字会医院妇产科,310003 [2]浙江大学医学院附属邵逸夫医院妇产科

出　　处：《浙江医学》2013年第21期1879-1881,1885,共4页Zhejiang Medical Journal

基　　金：杭州市科技发展计划项目(20100733Q26)

摘　　要：目的：探讨Toll样受体（Tol- like receptors/TLRs）9基因rs187084位点多态性与子宫内膜异位症（EMs）发病风险的关系。方法采用DNA直接测序法检测104例EMs患者（EMs组）和100例非EMs患者（对照组）的TLR9基因rs187084位点的多态性，比较各基因型和等位基因的分布情况。结果 EMs组和对照组中，TLR9基因rs187084位点的AA、AG、GG3种基因型频率分别为42.30%、28.85%、28.85%和52.00%、34.00%、14.00%，两组比较差异有统计学意义（P=0.036）；A、G等位基因频率分别为56.73%、43.27%和69.00%、31.00%，两组比较差异有统计学意义（P=0.01）；携带GG基因型明显增加EMs的发病风险（OR=1.911，95％CI 1.113～3.282）。结论 TLR9基因rs187084位点多态性与EMs的发病风险相关。Objective To investigate the association between single nucleotide polymorphisms of tol- like receptors （TLRs） 9 rs187084 and the risk of endometriosis. Methods One hundred and four cases of endometriosis and 100 healthy wom-en （control group） were enrol ed in the study. Single nucleotide polymorphisms of TLR 9 rs187084 were examined with DNA di-rect sequencing, and the gene type and the al ele frequency was analyzed. Results The percentages of AA, AG and GG geno-types on TLR9 rs187084 in endometriosis group were 42.30%,28.85%and 28.85%, while those in control group were 52.00%, 34.00%and 14.00%, respectively （P=0.036）. The frequencies of the A and G al eles in the two groups were 56.73%,43.27%and 69.00%,31.00%, respectively （P=0.01）. The genotype GG was associated with the risk of endometriosis （OR：1.911, 95%CI：1.113-3.282）. Conclusion The polymorphisms of TLR9 rs187084 are closely associated with the risk of endometriosis.

关 键 词：子宫内膜异位症 TOLL样受体9 基因多态性 

分 类 号：R711.71[医药卫生—妇产科学]