龙鹿胶囊治疗少弱精子症的多中心临床研究  

Multi-centered clinical trial of Longlu Capsule for oligoasthenospermia

作　　者：金保方[1] 张新东[1] 王志强[1] 林树栋[1] 杨晓玉[2] 夏国守[3] 孙大林 高永金[5] 唐志安[6] 李相如[7] 翟振彦[7] 

机构地区：[1]南京中医药大学男科学研究所南京210046 [2]江苏省人民医院生殖中心 [3]南京市中医院男科 [4]浙江省湖州市妇幼保健院 [5]江苏大学附属医院 [6]宜兴市人民医院 [7]山东省胜利油田胜利医院

出　　处：《中国男科学杂志》2013年第9期46-49,共4页Chinese Journal of Andrology

基　　金：本研究为国家自然科学基金（81273760）基金项目（基于“肾藏精”理论研究补肾填精法调控小鼠精原干细胞增殖及改善少弱精子症小鼠生精功能的作用及机制）、国家“973”国家重点基础研究发展计划课题（编号2010CB530401）基金项目（“肾藏精”理论文献与临床信息综合分析研究）

摘　　要：目的观察龙鹿胶囊治疗少弱精子症的疗效，并探讨其可能的作用机制。方法采用多中心、随机对照的临床研究，将确诊的360例患者随机分为对照组（160例）和治疗组（200例）。对照组服用VitE，100mg，bid；治疗组服用龙鹿胶囊，3粒，tid。两组治疗3个月后，分别检测精液质量（精液量、精子浓度、前向运动精子、精子DFI、精浆SOD）及女方受孕率。结果有330例患者完成了临床研究，治疗组在精液量、精子浓度、前向运动精子、精子DFI、精浆SOD方面较用药前，均有显著的改善（P〈0．05），并且疗效优于对照组（P〈0．05）。结论龙鹿胶囊可提高体内的抗氧化能力，改善精子质量及自然妊娠率，并未见明显不良反应。Objective To observe the efficacy of Longlu Capsule in the treatment of oligoasthenospermia and explore its probable mechanism. Methods Usig the multi-centered randomized controlled study, 360 infertile men with oligoasthenospermia were divided into two groups including the control group （160 cases） and the treatment group （200 cases）. The patients in the control group were administrated VitE, 100mg once, bid and the patients in the treatment group were given Longlu Capsule, three pills, tid. After the treatment for 3 months, Semen volume, spermatozoa density, prorsad spermatozoa rate, spermatozoa DFI, seminal SOD, and pregnancy rate were measured. Results A total of 330 patients accomplished the clinical trial. In the treatment group, the index of semen volume, spermatozoa density, prorsad spermatozoa rate, spermatozoa DFI, and seminal SOD, were obviously improved compared to that of pre-treatment （P〈0.05）. Meanwhile, an obvious amelioration in spermatozoa density, prorsad spermatozoa rate, spermatozoa DFI, seminal SOD, and pregnancy rate were found compared to that of the control group （P〈0.05）. Conclusion Longlu Capsule can evidently improve the seminal quality and natural pregnancy rate of oligoasthenospermia patients via increasing the anti-oxidant ability.

关 键 词：少精子症 弱精子症 龙鹿胶囊 

分 类 号：R698.2[医药卫生—泌尿科学]