贫血症小鼠血液介电特性的实验研究与分析  

Experimental Research and Analysis on Dielectric Properties of Blood in Anemia Mice

作　　者：沈斌[1] 梁艳秋[1] 高炜淇[1] 尤楚[1] 洪梦琪[1] 马青[1] 

机构地区：[1]宁波大学医学院,宁波315211

出　　处：《生物医学工程学杂志》2013年第6期1186-1190,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(51277099);宁波大学SRIP项目资助(2012417)

摘　　要：在0．1～100MHz频率范围，使用交流电阻抗方法测量小鼠血液的介电常数和电导率，通过Cole—Cole方程的数值计算和曲线拟合的残差分析，观察苯肼性贫血症小鼠血液介电谱Cole—Cole参数的改变。结果表明，苯肼引起小鼠红细胞比容（Hct）明显降低；血液介电常数（G）谱线向低介电绝缘区移动，血液介电性降低；血液电导率（一）谱线向高导电区移动，血液导电性增加；第二特征频率降低；苯肼致血液介电谱Cole-Cole参数的改变皆具有剂量依存性。The conductivity and permittivity of blood in mice were measured by the AC electrical impedance method at frequency range of 0. 1-100MHz, and then the changes of the Cole-Cole parameters of dielectric spectra of blood from phenylhydrazine induced anemia mice were observed by numerical calculation and curve fitting residual analysis of the Cole Cole equation. The results showed that hematocrit （Hct） of the mice with phenylhydrazine injection was signifi- cantly reduced; the permittivity（~） spectroscopy of blood moved to the low insulating region and its permittivity de- creased; conductivity spectrum curve of blood moved to the high conductivity zone and conductivity increased; the 2nd characteristic frequency was lower than that in the normal group. There was phenylhydrazine dose dependent in the changes of the Cole-Cole parameters of dielectric spectra of blood.

关 键 词：苯肼 小鼠 血液 介电谱 Cole—Cole方程 

分 类 号：R556[医药卫生—血液循环系统疾病] R318.04[医药卫生—内科学]