个体化碳/碳复合材料人工骨制备及应用  

Study on the Preparation and Application of Individual Artificial Bone with Carbon/carbon Composites

作　　者：倪昕晔[1,2] 钱农[1] 周栋[1] 缪云良 熊信柏[4] 林涛[1] 陈达[2] 赵公吟[1] 钟萍[1] 

机构地区：[1]南京医科大学附属常州第二人民医院,常州213003 [2]南京航空航天大学材料科学与技术学院,南京210016 [3]江苏天鸟高新科技有限公司,无锡214205 [4]深圳大学材料科学与工程学院,深圳518060

出　　处：《生物医学工程学杂志》2013年第6期1265-1271,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(51172147);江苏省常州市社会发展项目资助(CS20102019);南京医科大学校基金重点项目资助(2011NJMU226)

摘　　要：本研究主要探讨个体化碳/碳复合材料人工骨的制备及应用。利用计算机断层图像(CT)进行三维图像采集,对骨轮廓进行人工和自动勾画,并用二值体数据描述,采用移动立方体(marching cubes)算法得到三维物体的表面信息,再用geomagic软件转换成非均匀有理B样条(NURBS)曲面,最后通过数控加工中心加工得到个体化碳/碳复合材料人工骨。对兔子进行肱骨头更换,从影像学和病理切片来观察植入效果。研究结果表明,采用此方法加工的骨其形状与替换骨一致,且植入后与周围骨组织结合密切,表面骨组织生长良好。因此,此方法为个体化碳/碳复合材料人工骨制备奠定了一定的理论和实验基础。The present paper is aimed to study the preparation and application of individual artificial bone of carbon/ carbon composites. Using computer tomography images （CT）, we acquired a three-dimensional image. Firstly, we described bone contour line outlined with manual and automatic method by the binary volume data. Secondly,we cre- ated 3D object surface information by marching cubes. Finally, we converted this information to non-uniform rational B-spine （NURBS） by using geomagic software. Individual artificial bone with carbon/carbon composite was prepared through the CNC Machining Center. We replaced the humeral head of the tested rabbit, and then observed the effects of implantation in neuroimaging and pathological section. Using this method, we found that the bone shape processed and bone shape replaced was consistent. After implantation, the implant and the surrounding bone tissue bound closely,and bone tissue grew well on the surface of the implant. It has laid a sound foundation of the preparation u- sing this method for individual artificial bone of carbon/carbon composite material.

关 键 词：碳 碳复合材料 人工骨 个体化 

分 类 号：R318.08[医药卫生—生物医学工程]