益气助精颗粒治疗特发性少弱精子症的临床研究  

Yiqi Zhujing Granule for idiopathic oligoasthenozoospermia: A clinical study

作　　者：黄新飞[1] 何映[1] 樊千[1] 王庆[1] 宁克勤[1] 

机构地区：[1]江苏省中医院男科,江苏南京210029

出　　处：《中华男科学杂志》2013年第12期1119-1123,共5页National Journal of Andrology

摘　　要：目的:观察益气助精颗粒治疗特发性少弱精子症的疗效。方法:从2012年3月至2013年3月间,对78例男性不育患者中的特发性少弱精子症患者,随机分2组治疗,对照组(n=39)采用葡萄糖酸锌口服液,1支/次,2次/d,维生素E胶丸,100 mg/次,2次/d;治疗组(n=39)在对照组治疗药物的基础上加用益气助精颗粒,2次/d;疗程3个月。结果:经过治疗,对照组前向运动精子百分率和精子存活率较治疗前提高,差异具有统计学意义(P均<0.05);治疗组精子总数、精子浓度、前向运动精子百分率和精子存活率较治疗前提高,差异具有统计学意义(P均<0.05)。精子总数、精子浓度、前向运动精子百分率和精子存活率治疗前后的差值,治疗组较对照组改善明显,差异具有统计学意义(P均<0.05)。经过治疗,对照组和治疗组在精浆生化各指标上均有不同程度的改善,其中治疗组较对照组精浆锌、α-葡糖苷酶、酸性磷酸酶改善更为显著,差异具有统计学意义(P均<0.05);治疗组在精浆锌、精浆果糖和α-葡糖苷酶的改善上,与对照组提高的差值相比较,差异具有统计学意义(P<0.05)。治疗组治疗后精浆锌变化水平与精子浓度改善水平成正相关(r=0.201,P<0.05);精浆果糖变化水平与精子浓度改善水平呈负相关(r=-0.136,P<0.05);α-葡糖苷酶变化水平与精子存活率呈正相关(r=0.314,P<0.05)。结论:益气助精颗粒在提高精子总数、精子浓度、前向运动精子百分率、精子存活率,改善精浆锌、精浆果糖、α-葡糖苷酶、酸性磷酸酶上面有显著效果。Objective： To assess the efficacy of Yiqi Zhujing Particle in the treatment of idiopathic oligoasthenozoospermia. Methods： We equally randomized 78 patients with idiopathic oligoasthenozoospermia to a control group and a Yiqi Zhujing group, the former treated with oral medication of zinc gluconate liquid （ 10 ml, bid） and vitamin E （ 100 mg, bid）, and the latter given Yiqi Zhu- ring Granule （ 1 packet, bid） in addition, both for 3 months. We compared the semen parameters and biochemical indexes of the semi- nal plasma obtained before and after medication between the two groups of patients. Results ： After 3 months of treatment, remarkable improvement was observed in the percentage of progressively motile sperm and sperm viability in the control group （P 〈 0.05） as well as in the total sperm count, sperm concentration, percentage of progressively motile sperm, and sperm viability in the Yiqi Zhujing group （P 〈 0.05 ）. The total sperm count, sperm concentration, percentage of progressively motile sperm, and sperm viability were even more significantly improved in the Yiqi Zhujing than in the control group （ P 〈 0.05 ）. Besides, both groups showed different de- grees of improvement in the biochemical indexes of the seminal plasma, and the Yiqi Zhufing group exhibited even more significant im- provement in seminal plasma zinc, α-glucoside enzyme, seminal plasma fructose, and acid phosphatase than the control （P 〈 0.05）. The improvement of sperm concentration was correlated positively with the change of seminal plasma zinc （ r = 0. 201, P 〈 0.05 ） but negatively with that of seminal plasma fructose after treatment （r = -0. 136, P 〈 0.05）. There was a positive correlation between the ct-glucoside enzyme level and sperm viability （ r = 0.314, P 〈 0.05 ）. Conclusion ： Yiqi Zhujing Particle is effective for idiopathic ol- igoasthenozoospermia by significantly improving the total sperm count, sperm concentration, percentage of progressively motile sperm, sperm

关 键 词：少弱精子症 益气助精颗粒 男性不育 

分 类 号：R698.2[医药卫生—泌尿科学]