雄激素在婴儿肛周脓肿发病中的作用及机制探讨  

Role of androgen in the pathogenesis of perianal abscess in infants

作　　者：梁珣[1] 金先庆[1] 向丽[1] 袁亮[1] 侯金平[1] 

机构地区：[1]重庆医科大学附属儿童医院普外科,410014

出　　处：《中华小儿外科杂志》2013年第12期893-895,共3页Chinese Journal of Pediatric Surgery

摘　　要：目的研究血清雄激素水平与婴儿肛周脓肿发病的关系，探讨婴儿肛周脓肿的发病机制。方法以100例肛周脓肿男患儿为研究组，11例年龄3月龄以下的腹股沟疝（无嵌顿史）男患儿为对照组，采用化学发光法测定两组患儿的血清总睾酮、雄烯二酮、脱氢表雄酮浓度，并行统计学处理及相关性分析。结果研究组患儿血清睾酮水平（8．01±4．29）nmol／L较对照组的（4．55±1．23）nmol／L明显升高，差异有统计学意义（t=2．65，P〈0．05）；血清雄烯二酮水平（16．11±9．55）nmol／L较对照组的（6．78±2．30）nmol／L明显升高，差异有统计学意义（t=3．21，P〈0．05）；血清脱氢表雄酮水平（1．70±1．21）nmol／L较对照组的（1．23±0．65）nmol／L无明显升高，差异无统计学意义（t=1．24，P〉0．05）。结论雄激素增高可能与婴儿肛周脓肿的发病相关。Objective To investigate the relationship between the serum level of androgen and perianal abscess in infants and explore its mechanism in the pathogenesis. Methods One hundred male infants with perianal abscess （experimental group） and 11 male infants with inguinal hernia （without history of incarceration） under 3 months old （control group） were studied. Serum levels of total tes- tosterone, androstenedione, dehydroepiandrosterone were determined by chemiluminescence. Results Serum testosterone level in the experimental group[（8. 01 ± 4. 29）nmol/L] was significantly higher than that in the control group] （4. 55 ±1.23） nmol/L, t = 2.65, P〈0. 05] ; Serum androstenedione level [（16. 11±9. 5）nmol/L2 was significantly higher than that in control group [（6. 78 ±2. 30）nmol/ L, t = 3.21,P〈0. 052; Serum dehydroepiandrosterone level [（1.70 ± 1.21） nmol/L] had no obvious increase, compared to that in control group [（1.23 ± 0. 65） nmol/L, t = 1.24,P〈0. 05]. Conclusions Increased androgen may play a role in the pathogenesis of the perianal abscess in infants.

关 键 词：雄激素类 肛周腺 脓肿 

分 类 号：R726.5[医药卫生—儿科]