曲细精管内移植多能干细胞的研究  

Transplantation of Pluripotent Stem Cells in Seminiferous Tubules

作　　者：王嘉悦[1] 吴嫣爽[1] 单智焱[1] 孙瑞珍[1] 雷蕾[1] 

机构地区：[1]哈尔滨医科大学组织学与胚胎学教研室,胚胎与干细胞工程校重点实验室,哈尔滨150081

出　　处：《生殖与避孕》2013年第12期849-853,865,共6页Reproduction and Contraception

基　　金：国家自然科学基金面上项目;项目号:31271590

摘　　要：近年来,干细胞体内分化的研究得到了广泛的开展,其中干细胞曲细精管内移植与分化的相关研究取得了令人瞩目的进展,常用的曲细精管内移植的方法有曲细精管注射法、睾丸输出管注射法和睾丸网注射法,各有优缺点。所移植的细胞可以为精原干细胞、体外分化的胚胎干细胞和诱导多能性干细胞及成体干细胞,从而为研究睾丸细胞功能、生物学特性及更好地保存个体基因组和治疗某些疾病所引起的少精子症、无精子症提供强而有力的生物学工具。Stem cells are pluripotent and self-renewing cells, which can differentiate into specific tissue cell types under certain conditions. In recent years, the studies of stem cells differentiation in vivo have been widely carried out. Moreover, transplantation and differentiation of stem cells in the seminiferous tubules have made great progress, which may provide a novel clinical treatment for male infertility. In this review, we discussed the devel- opment of seminiferous tubules transplantation techniques and recent progresses of stem cells differentiation within the seminiferous tubules, and prospected the potential application in this field as well.

关 键 词：曲细精管 干细胞 移植 体内分化 

分 类 号：R698.2[医药卫生—泌尿科学]