SLC2A9基因第八外显子137A/G多态性变化与糖尿病合并高尿酸血症易感性的关系  

Association of 137A/G polymorphism of SLC2A9 gene with susceptibility of diabetes complicated hyperuricemia

作　　者：袁鹰[1] 侯丕秀[1] 苗志敏[1] 王颜刚[1] 胡文超[1] 赵文娟[1] 杜风丽 邢士超[1] 

机构地区：[1]青岛大学医学院附属医院内分泌科,266003

出　　处：《中华糖尿病杂志》2013年第11期661-665,共5页CHINESE JOURNAL OF DIABETES MELLITUS

基　　金：国家自然科学基金（81100554）;山东省优秀中青年科学家基金（BS2012YY003）;山东省医药卫生科技发展计划（2011QZ007）;青岛市科技发展计划（No.12-1-4-20-jch,2012-10-2-（1）-nsh,10-3-4-7-5-jch）

摘　　要：目的 探讨SLC2A9基因第八外显子137A/G多态性与糖尿病合并高尿酸血症的关系.方法 纳入2009至2010年在青岛医学院附属医院门诊和病房的患者312例,其中糖尿病患者103例（男59例,女44例）、高尿酸血症患者105例（男86例,女19例）、糖尿病合并高尿酸血症患者104例（男63例,女41例）,另选健康志愿者102名（男45名,女57名）.采用聚合酶链反应-限制性片段长度多态性技术进行多态性检测.结果 137A/G位点最小等位基因频率为37.9％.137A/G位点多态性与高尿酸血症、糖尿病合并高尿酸血症发病相关（x2 =4.075、4.392,均P＜0.05）,与单纯糖尿病无关（x2 =0.942,P＞0.05）.校正性别、年龄因素后,logistic回归分析表明携带G等位基因的个体患高尿酸血症、糖尿病合并高尿酸血症的风险比携带A等位基因的个体高（OR=1.523、1.632,均P＜0.05）,差异有统计学意义;与单纯糖尿病的发病风险无统计学意义（OR=1.121,P＞0.05）.结论 SLC2A9基因第八外显子137A/G多态性与高尿酸血症、糖尿病合并高尿酸血症的发病密切相关,而与单纯糖尿病无关.Objective To investigate the association between the 137A/G polymorphism of SLC2A9 gene and diabetes mellitus （DM） complicated hyperuricemia （HUA）.Methods A total of 102 healthy controls （45 males and 57 females）,103 patients with DM （59 males and 44 females）,105 patients with HUA （86 males and 19 females）,and 104 patients with DM complicated HUA （63 males and 41 females） were enrolled in the study from the Affiliated Hospital of Medical College of Qingdao University in 2009-2010.The polymerase chain reaction and restriction fragment length polymorphism （PCR-RFLP） method was used to detect the polymorphism.Results The minor allele frequency of 137A/G was 37.9％.Chi-square test revealed that 137A/G polymorphism was both significantly associated with HUA as well as DM complicated HUA（x2 =4.075,4.392,both P ＜ 0.05）,but not with pure DM （x2 =0.942,P ＞0.05）.After adjustment for age and gender,logistic regression analysis showed that people with G allele had higher risk of HUA and DM complicated HUA than those without G allele （OR =1.523,1.632,both P ＜ 0.005）,no association with pure DM（OR =1.121,P ＞ 0.05）.Conclusion The 137A/G polymorphism of SLC2A9 gene is closely associated with HUA as well as DM complicated HUA,but not with DM.

关 键 词：糖尿病 高尿酸血症 基因 SLC2A9 多态性 

分 类 号：R587.1[医药卫生—内分泌] R589[医药卫生—内科学]