糖原合酶激酶-3,一个参与多种信号通路的重要调节因子  

Glycogen Synthase Kinase-3,a Key Regulator of Signaling Pathways

作　　者：宾晓芸[1] 姜明国[2] 翁汉荣 

机构地区：[1]右江民族医学院基础医学院生物化学与分子生物学教研室,广西百色533000 [2]广西民族大学海洋与生物技术学院,广西南宁530008 [3]美国佐治亚州佐治亚大学药学和生物医学系,雅典ga30602

出　　处：《中国生物化学与分子生物学报》2013年第12期1120-1127,共8页Chinese Journal of Biochemistry and Molecular Biology

基　　金：广西自然科学基金项目(No.2012GXNSFAA053038);国家自然科学基金项目(No.31260004)~~

摘　　要：糖原合酶激酶-3(glycogen synthase kinase-3,GSK-3)是一种多功能的丝氨酸/苏氨酸蛋白激酶,在蛋白质合成、信号传递、细胞增殖、细胞分化、神经功能、肿瘤形成及胚胎发育等众多细胞进程中均扮演重要的角色.GSK-3能够使多种底物发生磷酸化,并参与胰岛素、Wnt及Hedgehog等多个信号通路的调控.GSK-3抑制剂在信号通路中能有效地抑制病理情况下GSK-3活性的异常增高,达到治疗的目的.GSK-3的抑制剂将作为一种潜在的药物对治疗糖尿病、阿尔海默茨症、肿瘤等疾病发挥效用.Glycogen synthase kinase-3 （GSK-3） is a multi-functional serine/ threonine kinase involved in various physiological processes, such as metabolism, cell cycle, gene expression, development and oncogenesis to neuroprotection. Recently, it was shown that GSK-3 plays a key role in many signaling pathways by phosphorylating specific serine and threonine residues of the substrates. Inhibitor of GSK-3 effectively alieviated the pathological condition in several diseases, and started to be considered a potential drugs. We summarized the highlighted the reports on the mechanisms of GSK-3 in the regulation of insulin, Wnt/13-catenin and Hedgehog pathway, cancer and Alzheimer＇ s disease. and discussed GSK as the potential target in diabetes,

关 键 词：糖原合酶激酶-3 胰岛素 WNT HEDGEHOG 调控 

分 类 号：R966[医药卫生—药理学]