fMRI观察高温环境下人脑静息态神经活动变化及意义  

fMRI observation on resting state functional pattern during passive hyperthermia

作　　者：钱绍文[1] 刘锴[1] 李勃[1] 李敏[1] 李理[1] 杨晓[1] 杨震[1] 姜庆军[1] 孙钢[1] 

机构地区：[1]济南军区总医院医学影像科,山东济南250031

出　　处：《中国医学影像技术》2013年第12期1931-1936,共6页Chinese Journal of Medical Imaging Technology

摘　　要：目的采用静息态功能连接(FC)与低频振幅(ALFF)技术,结合注意网络测试(ANT),探讨高温下人脑静息态神经活动变化及意义。方法令18名被试按随机交叉顺序在高温(50℃)与常温(25℃)下暴露1h后,采集fMRI数据,扫描结束后进行ANT测试。采用FC与ALFF分析fMRI数据,得到全脑FC网络与ALFF图,分别对其进行配对t检验,并对额-顶区ALFF与FC变化与注意网络效应值进行相关分析。结果额眶区与颞叶、顶叶和枕叶等脑区连接显著降低,颞叶与额眶区、对侧颞叶、顶叶和枕叶连接显著降低,而脑岛、基底核区和丘脑以及额顶躯体感觉运动区等连接显著升高。前额叶背外侧、额眶区、颞叶等区域神经活动降低,而右侧躯体感觉运动区、丘脑及周围神经核团神经活动大幅度增强。执行控制效应降低与ALFF及FC改变显著相关。结论高温下人脑静息态成像模式的变化可能反映了高温下认知功能改变的神经学基础与中枢神经系统自主调节与行为调节机制。Objective To explore the impact of passive hyperthermia on neural activity using resting state functional connectivity （FC） and amplitude low frequency fluctuation （ALFF） combined with behavioral attention network test. Methods Eighteen participants experienced a hyperthermic condition （50℃） and a normal condition （25℃） for 1 h in a random cross over design. After hyperthermia exposure, resting state fMRI were performed, and then a behavioral attention network test was performed on each participant. FC and ALFF were used to explore significant alterations using paired t-test. Results FC analysis revealed significant decreased connectivity in orbital frontal cortex with temporal lobe, parietal lobe and occipital lobe, and temporal lobe with orbital frontal cortex, contralateral temporal lobe, parietal lobe and occipital lobe. Meanwhile, connectivity in insula, basal ganglia, thalamus and fronto-parietal somatosensory cortex increased significantly. ALFF analysis implied that neural activity in dorsolateral prefrontal cortex, orbital frontal cortex and temporal lobe decreased, while activity in right somatosensory cortex, thalamus and surrounding nucleus increased. Behavioral attention network test showed that executive control effect was correlated with the alterations of ALFF and FC. Conclusion The alterations of resting state functional pattern may imply the neural basis of cognition performance alteration, and autonomic and behavioral thermoregulation mechanism of central nervous system.

关 键 词：高温 诱发 功能连接 低频振幅 注意网络 

分 类 号：R134.3[医药卫生—劳动卫生] R445.2[医药卫生—公共卫生与预防医学]