活性氧在创伤愈合中作用的研究  

The Review on Role of Reactive Oxygen Species in Wound Healing

作　　者：王佳琪[1] 王国栋[1] 吴洋[1] 

机构地区：[1]第二军医大学附属长征医院口腔科,上海200003

出　　处：《现代生物医学进展》2013年第31期6194-6196,共3页Progress in Modern Biomedicine

基　　金：上海市自然科学基金项目(09ZR1410600)

摘　　要：创伤愈合是一个复杂的生物学过程,包括出血与凝血、炎症渗出、血管和肉芽组织的形成、再上皮化、纤维化和瘢痕改建等,在这一系列的生物学活动过程中都需要能量支持;高等动物使用氧气作为终端氧化剂,通过对碳水化合物的氧化作用为愈合过程中的各种生命活动提供能量,但该过程却可以产生大量的活性氧,这些活性氧在创伤愈合的过程中扮演着重要的角色,在低浓度情况下可以促进伤口的愈合,而在高浓度时会抑制伤口愈合,而活性量浓度的过高过低都会影响创口的正常愈合过程。Wound healing is a complex process involving several stages that include inflammation, formation of granulation tissue, reepithelialization, matrix formation and remodeling. The energy supports these biological processes. High organisms utilize molecular oxygen as a terminal oxidant. This way of gaining energy for wound healing leads to the production of a number of reaction oxygen species which may have a defensive or informatory role in wound healing. The low concentration of ROS would improve the wound healing, while it may be harmful in high concentrations. Both the lack and the excess of reactive oxygen species may influence healing negatively.

关 键 词：创伤愈合 活性氧 

分 类 号：R713.5[医药卫生—妇产科学]