速眠新Ⅱ与氯胺酮复合麻醉对巴马小型猪呼吸与循环的影响  

Effect of Compound Anesthesia by SumianxinⅡ with Ketamine on Respiration and Circulation Systems of Bama Minipigs

作　　者：颜克松[1] 陆承荣[2] 罗渊[2] 战大伟[1] 王喆[2] 

机构地区：[1]解放军总医院第一附属医院实验动物科,北京100048 [2]空军总医院临床航空医学中心实验室,北京100142

出　　处：《中国畜牧兽医》2013年第12期193-195,共3页China Animal Husbandry & Veterinary Medicine

基　　金：重大新药创新科技重大专项(2008ZX09203-007)

摘　　要：试验旨在观察速眠新Ⅱ、速眠新Ⅱ与氯胺酮复合麻醉对巴马小型猪呼吸与循环功能的影响。试验选取成年健康巴马小型猪20只,分为速眠新Ⅱ组、速眠新Ⅱ与氯胺酮复合组,每组10只。速眠新Ⅱ组诱导时肌内注射速眠新Ⅱ0.1mL/kg;速眠新Ⅱ与氯胺酮复合组采用肌内注射配比度为1∶2(V/V)的速眠新Ⅱ与氯胺酮0.2mL/kg。监测诱导前、后呼吸频率(RR)、血氧饱和度(SpO2)、呼气末二氧化碳(PET CO2)、心率(HR)和平均动脉压(MAP)等参数。结果显示,诱导后1min速眠新Ⅱ组RR、SpO2、MAP、HR与诱导前相比均显著下降(P<0.05),通气量(VE)极显著下降(P<0.01)。速眠新Ⅱ与氯胺酮复合组诱导前、后呼吸循环参数之间均无显著变化(P>0.05)。因此,速眠新Ⅱ与氯胺酮复合麻醉避免了单独使用速眠新Ⅱ对呼吸与循环系统抑制的不良反应,安全可靠。The assay was aimed to observe the effects of anesthesia by sumianxin Ⅱ,sumianxin Ⅱ combined with ketamine on respiration and circulation systems of Bama Minipigs.20 healthy grown Bama Minipigs were set for two groups, each contained 10. One group was induced with intramuscular injection of 0.1 mL/kg sumianxinⅡ, another group with intramuscular injection of 0.2 mL/kg mixture sumianxinⅡ and ketamine （1：2, V/V）. The respiration rate （RR） before and after induction of these chemicals were observed respectively before surgery. Furthermore, SpO2, PETCO2, heart rate （HR）, mean artery pressure （MAP） and other data were monitored as well before surgery. The results were that RR, SpO2, MAP and HR decreased significantly 1 min after treatment of sumianxin Ⅱ （P〈0.05）. VE was also found to extremly significantly decrease （P〈0.01）. However, all observed data had no significant change before and after induction by sumianxin Ⅱ together with ketamine （P〉0.05）. Thus,the compound anesthesia by sumianxin Ⅱ with ketamine had no clear side effect on respiration and circulation systems. This kind of compound anesthesia was safe and reliable for surgery.

关 键 词：巴马小型猪 速眠新Ⅱ 氯胺酮 复合麻醉 呼吸 循环 

分 类 号：Q592.1[生物学—生物化学]