GR G678S、GRBclⅠ基因多态性与原发性高血压的关系  

The relationship between GR G678Sand GR BclⅠgene polymorphism and essential hypertension

作　　者：沈波[1] 陈惠[2] 王李仁[1] 刘宝英[3] 周慧[3] 

机构地区：[1]福州市疾病预防控制中心,福建350004 [2]福建省肿瘤医院,福州350014 [3]福建医科大学,福州350004

出　　处：《海峡预防医学杂志》2013年第4期8-11,共4页Strait Journal of Preventive Medicine

基　　金：福建省医学创新课题(No.2007-CX-8);福建医科大学公共卫生学院重点学科发展基金项目(No.GW09)

摘　　要：目的探讨糖皮质激素受体(GR)G678S和GR BclⅠ基因多态性与原发性高血压(EH)的关系。方法选择高职业应激的男性196人为研究对象,与对照组比较(1∶1),用PCR-RFLP技术检测基因型,用logistic回归分析GR基因多态性与EH的关系。结果 GR G678S携带TC基因型与CC基因型相比,调整混杂因素后,患EH的OR值为0.750。GR BclⅠ携带GG基因型和CG基因型+GG基因型分别与CC基因型比较,OR值分别为2.270和1.599。结论 G678S基因多态性未发现与EH有明显相关,GR BclⅠ基因多态性可能与EH有关。Objective To explore the relationship between glucocorticoid receptor（GR）G678S,GR BclⅠgene polymorphism and essential hypertension（EH）.Method Totally 196males of occupational stress high-exposure were investigated and compared with control group（1：1）.The genotypes were detected by PCR-RFLP technology and the relationship between polymorphisms and EH were analyzed by logistic regression model.Results The value OR of GR G678Scarrying the TC genotype was 0.750with the CC genotype.The value OR of GR BclⅠcarrying the GG and CG＋GG genotype was 2.270and 1.599with the CC genotype respectively after adjustment for confounding factors.Conclusion GR BclⅠgene polymorphism may be associated with essential hypertension while not happened in G678S.

关 键 词：原发性高血压 糖皮质激素受体 基因多态性 

分 类 号：R544.1[医药卫生—心血管疾病]