原发性高血压患者血浆一氧化氮、内皮素、血管紧张素Ⅱ的变化及硝苯地平对其影响  

The change of plasma NO ET,AngⅡ in patients with essential hypertension and the effect of nifedipine on them

作　　者：韩文余 严金川 凌玲 童加义[1,2] 

机构地区：[1]镇江市第四人民医院心内科,212001 [2]南京铁道医学院,210009

出　　处：《镇江医学院学报》1999年第4期525-526,共2页Journal of Zhenjiang Medical College

摘　　要：目的:通过对高血压患者血浆一氧化氮(NO)、内皮素(ET)血管紧张素(Ang)含量测定,观察钙拮抗剂、硝苯地平对其影响,方法:检测50例高血压病患者治疗前后和50例正常对照组血浆NO、ET、Ang浓度变化,结果:高血压患者血浆NO浓度较对照组低,ET、Ang较对照组高,并且NO、ET水平与舒张压水平相关;硝苯地平治疗后高血压患者血浆NO含量升高,ET、Ang水平下降,结论:NOET、Angg参与高血压的发生和发展并与病情相关,钙拮抗剂升高血浆NO,降低ET、Ang浓度可能是其治疗高血压的重要机制。s Objectire:To evaluate the effects of calcium antagonists Nifedipine on plasma NO\,ET\,Ang Ⅱ levels in essential hypertension before and after the treatment.Methods :Plasma NO\,ET\,AngⅡ were measured in 50 patients with essential hypertension before and after the treatment and in 50 control subjects.Results: The plasma No level was lowerin hypertensive patients than that in control subjects ( P <0 01)while ET\,AngⅡ levels were higher than those in control subjects,and NO\,ET is relatedto DBP The plasma NO level was increased and ET AngⅡ levels were reduced after nifedipine treatment.Conlusion: plasma NO\,ET\,AngⅡare associated with the development of hypertensionand related to the severity of hy pert ension.The mechanisms of calcium antagonists in hypertensive treatment are due to the increase of NO and the decrease of AngⅡ ET.

关 键 词：原发性高血压 一氧化氮 内皮素 血管紧张素Ⅱ 

分 类 号：R544.1[医药卫生—心血管疾病]