牛蒡苷抗炎和解热作用研究  

Anti-inflammation and antipyretic effects of arctiin

作　　者：张淑雅[1] 王小萍[2] 陈昕[1] 芦晓红[1] 张宏[3] 裴秀英[1] 

机构地区：[1]宁夏医科大学生育力保持教育部重点实验室/生物化学与分子生物学系,宁夏银川750004 [2]宁夏医科大学总医院药剂科,宁夏银川750004 [3]第二军医大学药学院 药用植物学教研室,上海200433

出　　处：《药物评价研究》2013年第6期422-425,共4页Drug Evaluation Research

基　　金：国家自然科学基金资助项目(81360094;81260110);宁夏科技支撑计划项目(宁科计字[2012]17)

摘　　要：目的研究牛蒡苷的抗炎和解热作用,为牛蒡苷及牛蒡子的临床应用提供依据。方法应用小鼠耳廓肿胀模型、大鼠肉芽肿和弗氏完全佐剂模型观察牛蒡苷对急慢性炎症的影响,采用大肠杆菌内毒素发热家兔模型观察牛蒡苷的解热作用。结果牛蒡苷在60、120、240 mg/kg剂量下显著减轻二甲苯所致小鼠耳廓肿胀,减少大鼠肉芽组织增生,明显降低发热家兔体温,但并不改善佐剂性关节炎大鼠足关节肿胀程度。结论牛蒡苷具有良好的抗急性炎症和解热作用。Objective The anti-inflammatory and antipyretic activities of arctiin in animals were investigated to guide the clinical applications of arctiin and Arctii Fructus.Methods The anti-inflammatory activity was assessed using the inflammation models induced by dimethylbenzene,croton oil and Freund＇s complete adjuvant in mice or rats.The antipyretic effect was estimated using the rabbit fever model elicited by Escherichia coli endotoxin.Results Arctiin could significantly alleviate the ear swelling of mice,the proliferation of granulation tissue of rats,and fever of rabbits,but could not ameliorate the paw edema induced by Freund＇s complete adjuvant in rats.Conclusion Arctiin possesses the anti-inflammatory effect on the acute inflammation and has the antipyretic activity.

关 键 词：牛蒡苷 炎症 发热 

分 类 号：R971.1[医药卫生—药品]