阿齐沙坦油水分配系数的测定  

Determination of oil-water partition coefficient of Azilsartan

作　　者：米楠[1] 苏慕君[1] 臧可昕[1] 

机构地区：[1]天津药物研究院,天津300193

出　　处：《药物评价研究》2013年第6期452-454,共3页Drug Evaluation Research

摘　　要：目的测定阿齐沙坦的油水分配系数。方法配制不同pH值的磷酸盐缓冲液,以正辛醇-磷酸盐缓冲液作为分散系统,摇瓶法作为测定方法,照紫外-可见分光光度法(《中国药典》2010年版附录ⅣA)进行测定。通过阿齐沙坦分配平衡后在油相(正辛醇)和水相的浓度比,计算油水分配系数。结果在正辛醇-磷酸盐缓冲液体系中,pH=3.0时阿齐沙坦的油水分配系数为3.78,pH=7.0时阿齐沙坦的油水分配系数为0.30。结论应用摇瓶-紫外分光光度法,能够准确测定阿齐沙坦的油水分配系数,并由此推测其体内过程。Objective To determine the oil-water partition coefficient of Azilsartan.Methods A shake flask-ultraviolet spectrophotometry method was applied to determining the oil-water partition coefficient of Azilsartan in n-octanol-buffer solution systems with different pH values.Results The LgP of Azilsartan under pH 3.0 was 3.78 and pH 7.0 was 0.30.Conclusion The shake flask-ultraviolet spectrophotometry method can be used to determine the oil-water partition coefficient of Azilsartan,and help to predict the in vivo process.

关 键 词：阿齐沙坦 油水分配系数 紫外分光光度法 

分 类 号：R94[医药卫生—药剂学]