葛根素、川芎嗪、丹参注射液对家兔软脑膜微循环的影响  

Effect of Puerarin, Tetramethyl Pryazine and Injection of Salvia Miltiorrhiza Bunge on Pial Microcirculation in Rabbits

作　　者：王世军[1] 史仁华[1] 姬广臣[1] 张连才[1] 周恩平[1] 

机构地区：[1]山东中医药大学病理教研室,济南250014

出　　处：《微循环学杂志》1999年第4期19-21,共3页Chinese Journal of Microcirculation

基　　金：山东省自然科学基金!94C0 72 3

摘　　要：目的 :探讨葛根素、川芎嗪、丹参注射液治疗脑血管疾病的疗效机制。方法 :采用闭合式颅骨开窗法 ,应用多部位微循环观察仪及微循环计算机图像处理系统 ,观察用药前后家兔软脑膜微血管管径及血流速度的变化。结果 :正常家兔静脉注射葛根素 ( 5 0 mg/kg) ,对微血管的管径及血流速度的影响较小 ;静脉注射丹参注射液 ( 1ml/ kg)、川芎嗪 ( 2 0 ml/ kg)、维脑路通 ( 1ml/ kg)均有扩张微动脉、增加微动脉血流速度的作用 ,对微静脉作用较小。其中丹参注射液作用最为明显。结论 :静脉注射丹参注射液、川芎嗪、维脑路通系通过扩张软脑膜微动脉、增加微动脉血流速度而达到治疗目的。Objective: To investigate the effects puerarin, tetramethyl pryazine and injection of salvia miltiorrhiza bunge on pial microvessels diameter and blood flow velocity in rabbits. Method: Using multi region microcirculation observing system and microcirculatory image processing system and applying closed cranial window method, the pial microvessels diameter and blood flow velocity were recorded. Result: In normal rabbits, intravenous injection of puerarin(50 mg/kg), caused little change in pial microvessels diameter and blood flow velocity. Intravenous injection of tetramethyl pryazine(20 mg/kg), injection of salvia miltiorrhiza bunge(1 ml/kg) and injection of venoruton(1 ml/kg) can all dilate the pial atreriol and increase its blood flow velocity with less evident change on pial veinules. Conclusion: The result indicates that tetramethyl pryazine and injection of salvia miltiorrhiza bunge can all dilate the pial atreriol and increase its blood flow velocity with less evident change on pial veinules.

关 键 词：葛根素 川芎嗪 药理 脑微循环 丹参注射液 

分 类 号：R285.5[医药卫生—中药学]