140例强直性脊柱炎患者的心功能变化及相关性分析  

Changes of Heart Function of 140 Cases with Ankylosing Spondylitis and Relative Analysis

作　　者：齐亚军[1] 刘健[2] 曹云祥[2] 孙玥[1] 王芳[1] 叶文芳[1] 

机构地区：[1]安徽中医药大学,安徽合肥230031 [2]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《风湿病与关节炎》2013年第12期5-8,共4页Rheumatism and Arthritis

基　　金：国家中医药重点学科中医痹病学建设项目-国中医药发〔2009〕30号;安徽省科技厅科研计划项目(11010402170);安徽中医内科应用基础与开发研究省级实验室项目(科条〔2008〕150号);安徽中医学院科技创新团队项目(2010TD005)

摘　　要：目的:研究强直性脊柱炎患者心功能变化及与其他指标的相关性。方法:采用超声心动图(UCG)检测强直性脊柱炎140例患者心功能变化,并与正常对照组30例进行比较,观察强直性脊柱炎患者临床症状、体征及实验室指标与心功能参数相关情况,以探讨其作用机制。结果:①强直性脊柱炎组UCG心功能变化检测结果异常率为33.56%,正常对照组异常率为9.99%,两组比较,差异有统计学意义(P<0.01)。②强直性脊柱炎患者舒张晚期血流峰值(A峰)显著升高(P<0.01);舒张早期血流峰值(E峰)、射血分数、E/A比值显著降低(P<0.01)。③Spearman相关分析结果显示,强直性脊柱炎组患者心功能参数E峰与白细胞介素-10,A峰与心悸均呈显著正相关(P<0.05或P<0.01)。E峰与病程、食欲减退、少气懒言、食后腹胀、大便稀溏、血小板计数、尿酸、免疫球蛋白G、红细胞沉降率、C-反应蛋白,E/A比值与病程、食欲减退、少气懒言、食后腹胀、大便稀溏、a-酸性糖蛋白、白细胞介素-17,射血分数与病程、心悸、倦怠乏力、食后腹胀、C3,FS,%与少气懒言、三酰甘油均呈显著负相关(P<0.05或P<0.01)。结论:强直性脊柱炎患者存在心功能下降,表现为A峰升高,E峰、射血分数、E/A比值降低,且与症状体征积分、实验室指标相关。强直性脊柱炎患者心功能下降的机制可能是由于其体内免疫功能紊乱及细胞因子失衡引起心肌受损导致。Objective：To study the changes of heart function of patients with ankylosing spondylitis and analyze their correlativity with other indexes.Methods：Changes of heart function of 140 cases with ankylosing spondylitis were detected by ultrasonic cardiogram（UCG）and compared with those of 30 cases in the normal control group,observing their clinical symptoms,signs,laboratory indexes and their correlativity with parameters of cardiac function and exploring the mechanism.Results：①The abnormal rate of the ankylosing spondylitis group was 33.56% by UCG,while that of the normal control group was 9.99%,the difference being statistically signiifcant （P〈0.01）.②The blood stream peak of the late diastole（peak A）in the patients with ankylosing spondylitis increased signiifcantly（P〈0.01）;the blood stream peak of the early diastole（peak E）,the ejection fraction（EF） and the ratio of E/A decreased signiifcantly （P〈0.01）. ③ The Spearman correlation analysis showed that there were positive correlations respectively between the heart function parameter peak E and interleukin-10,and between peak A and palpitations （P 〈 0.05 or P 〈 0.01）.There were negative correlations respectively between peak E and duration of disease,loss of appetite,few words due to deficiency of qi,abdominal distention after eating,loose stool,blood platelet count,uric acid,immunoglobulin G,erythrocyte sedimentation rate and C-reactive protein,between E/A ratio and the course of disease,loss of appetite,few words due to deifciency of qi,abdominal distention after eating,loose stool,a-acidoglycoprotein and interleukin-17,between ejection fraction（EF）and the course,palpitations,fatigue,a bdominal distention after eating,C3,and between FS and few words due to deifciency of qi and triglyceride（P〈0.05 or P〈0.01）.Conclusion：The cardiac function of patients with ankylosing spondylitis decreased,manifesting on the aspects of the increase of peak A and the decrease of peak E,ejection fraction（EF）and the

关 键 词：脊柱炎 强直性 超声心动图 心功能 相关性分析 

分 类 号：R593.23[医药卫生—内科学]