半乳糖凝集素-3对慢性心力衰竭的诊断价值  

The role of galectin-3 in the diagnosis of chronic heart failure

作　　者：张育民 李庆宽 全勇 刘国兵 李峰 肖晓霞 史桂霞 

机构地区：[1]长沙市第三医院,长沙410015

出　　处：《中国医师杂志》2013年第11期1446-1449,共4页Journal of Chinese Physician

基　　金：基金项目：长沙市科技局项目基金（K1205027-31）

摘　　要：目的观测半乳糖凝集素-3（Gal-3）在慢性心力衰竭患者中的水平及其诊断价值。方法选择慢性心力衰竭患者]08例，按纽约心功能分级分成三组（Ⅱ、Ⅲ、Ⅳ级），键康对照组30例，所有病例均行心脏彩超检查，抽血检测Gal-3、B型脑利钠肽前体（NT—proBNP）及白细胞介素-6（IL．6）浓度。结果心衰组的Gal-3水平明显高于对照组（P〈0．05），与NYHA心功能分级呈正相关；相关性分析显示，Gal-3水平与NT．proBNP、IL-6呈正相关；Gal-3水平与左心室直径（LVD）、左室射血分数（LVEF）不相关。结论心衰患者血清Gal-3水平明显增高，升高水平与心衰程度显著相关；Gal．3可能作为心衰的新生化标志物，联合NT-proBNP可提高对心衰的诊断及其预后的判断。Objective To investigate serum galectin-3 levels in patients with chronic heart failure and evaluate its clinical significance for heart failure. -Methods A total of 108 chronic heart failure patients were selected. The selected patients were divided into three groups according to the classification of New York Heart Association （NYHA, from degree II to IV）. In addition, 30 healthy persons were chosen as control group. All the patients received cardiac ultrasound examination. Plasma levels of N-terminal pro- brain natriuretic peptide （NT-proBNP）, serum levels of galectin-3 and interleukin-6 （IL-6） were measured and analyzed. Results Galeetin-3 levels were significantly higher in chronic heart failure patients com- pared with control group（ P 〈 0.05 ）. In chronic heart failure group, the increase of serum concentration of galectin-3 was correlated with the degree of NYHA function classification. Correlation analysis showed that blood level of galectin 3 was strongly positive correlation with concentration of NT-proBNP and IL-6. There was no correlation between galectin-3 with the cause of heart failure, left ventricular diameter（ LVD）, and left ventricular ejection fraction （LVEF）. Conclusions The levels of galectin-3 was significantly increased in chronic heart failure, and was correlated with degree of heart failure. Galectin-3 might be a new biomark- er of heart failure and could provide additive value to NT-proBNP levels in the diagnosis of heart failure.

关 键 词：半乳糖凝集素3 血液 心力衰竭 诊断 利钠肽 脑 血液 白细胞介素6 血液 

分 类 号：R541.6[医药卫生—心血管疾病]