糖化血红蛋白和同型半胱氨酸在老年非糖尿病冠心病中的临床价值  

Clinical value of glycosylated hemoglobin and homocysteine in nondiabetic elder patients with coronary heart disease

作　　者：袁惠敏[1] 张江蓉[1] 王燕[1] 

机构地区：[1]上海交通大学医学院附属新华医院老年医学科 ,上海200092

出　　处：《中国医师杂志》2013年第11期1454-1457,共4页Journal of Chinese Physician

基　　金：基金项目：上海市干部保健局课题（2011GB17）

摘　　要：目的测定老年非糖尿病冠心病（CHD）患者糖化血红蛋白（HbAlC）和同型半胱氨酸（Hey）的水平，并探讨其临床意义。方法选择老年非糖尿病CHD患者86例（急性冠脉综合征组45例和稳定型心绞痛组41例），非糖尿病非CHD患者60例为对照组，测定并比较各组HbAlc和Hey的水平，分析两者的关系。结果老年非糖尿病CHD组HbAlc和Hey均高于对照组，急性冠脉综合征组HbA!C和Hcy水平高于稳定型心绞痛组，差异均有统计学意义（P〈0．05）；HbAlc和Hcy水平变化呈正相关（r=0．34，P〈0．05）。结论在非糖尿病CHD患者中存在HbAlc和Hey升高，且随CHD程度的加重而上升，提示HbAlc和Hey是心血管风险的预测因子。Objective To investigate hemoglobin Alc（HbAlc）and homocysteine （Hcy） in non- diabetic elder patients with coronary heart disease （CHD）, and explore their clinical value. Methods Eighty-six non-diabetic elder patients with CHD [ 45 cases with acute coronary syndrome （ACS） and 41 ca- ses with stable angina peetoris （SAP） ] and sixty elder patients without diabetes mellitus and coronary heart disease as control group were selected. The plasma levels of HbA1 c and Hey in all groups were detected and analyzed. Results The levels of HbAlc and Hcy in CHD group were significantly higher than those in con- trol group （ P 〈0. 05） , and levels of HbAlc and Hcy in ACS group were both higher than SAP group （ P 〈0. 05）. The change of HbAlc and Hcy had positive correlation （ r =0. 34, P 〈0. 05）. Conclusions The levels of HbAlc and Hcy were higher in non-diabetic elder patients with CHD than those without CHD, and might correlate with atherosclerosis. HbA1 c and Hey might be markers of cardiovascular risk.

关 键 词：血红蛋白A 糖基化 分析 半胱氨酸 代谢 冠心病 老年人 

分 类 号：R541.4[医药卫生—心血管疾病]