HBV感染者血清总胆汁酸含量的测定及其临床意义  

DETERMINATION OF SERUM TOTAL BILE ACID IN HEPATITIS B VIRUS INFECTED PATIENTS AND ITS CLINICAL SIGNIFICANCE

作　　者：鲁涛[1] 程恳[1] 王君[2] 

机构地区：[1]中日友好医院检验科,北京100029 [2]北京潞河医院检验科,北京101149

出　　处：《中日友好医院学报》2000年第6期325-328,共4页Journal of China-Japan Friendship Hospital

摘　　要：目的 :通过检测乙型肝炎病毒 (HBV)感染者血清总胆汁酸 (TBA)的含量 ,探讨该指标在乙型肝炎诊治中的意义。方法 :采用全自动酶法分析技术对 60 0份HBV感染者及 1 0 0份正常对照组血清进行空腹总胆汁酸测定 ,同时对其他肝功能相关项目进行测定。结果 :“1 35”、“1 45”、“2 4 5”、“5”模式组血清TBA含量与正常对照组相比 ,差异显著 (P <0 0 1 ,P <0 0 5)。“2 5”、“45”模式组血清TBA含量与正常对照组相比 ,差异不显著 (P >0 0 5)。结论 :TBA是一项比较灵敏的肝功能指标 ,它不仅可以帮助医生及早发现HBV携带者肝脏损伤的情况 。Objective:To explore the clinical significance in the diagnosis of hepatitis B by testing the serum total bile acid(TBA) of HBV infected patients.Methods:Serum from 600 HBV infected patients were measured for TBA by enzyme analysis and other liver function tests were also done.TBA of 100 normal serum specimens were measured for comparison.Results:The level of serum TBA in group '135','145','245' and '5' was significantly different from that of normal serum( P <0 01, P <0 05).The level of serum total bile acids in group '25' and group '45' had no significant difference from that of normal serum.Conclusion:The TBA is a sensitive assay of liver function.It is useful for doctor to discover and estimate the liver injury of HBV carriers.It can also help doctor to monitor the effect of treatment on hepatitis B patients.

关 键 词：乙型肝炎病毒感染 血清 总胆汁酸 含量测定 

分 类 号：R446.1[医药卫生—诊断学]