固体分散技术和包合技术对白头翁总皂苷增溶作用研究  

Study on solubilization effect of solid dispersion technology and inclusion technology on Pulsatillae total saponins

作　　者：管咏梅[1] 张妮[1] 陈振华[2] 刘红宁[1] 朱卫丰[1] 陈丽华[1] 杨明[1] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,江西南昌330004 [2]江西科技师范大学药学院,江西南昌330013

出　　处：《中国中药杂志》2013年第23期4061-4066,共6页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2013ZX09103002-001);江西省落地计划项目(赣财教[2011]243号);江西省卫生厅中医药科研课题(2012A152);江西省自然科学基金项目(20122BAB215041);江西省卫生厅项目(2012A036)

摘　　要：目的:考察固体分散技术及包合技术对白头翁总皂苷(白头翁总皂苷)溶出性能的影响并初步探讨其机制。方法:采用熔融法制备白头翁总皂苷-PEG 4000固体分散体,用冷冻干燥法制备白头翁总皂苷-羟丙基-β-环糊精(HP-β-CD)包合物,通过IR,DSC,NMR鉴定固体分散体及包合物性质,并采用小杯法测定了固体分散体及包合物的溶出度。结果:IR,DSC,NMR的结果表明形成了固体分散体及包合物;溶出度大小依次为包合物>固体分散体>原料药。结论:包合技术能显著提高白头翁总皂苷的溶出性能,而固体分散技术对其增溶作用不明显。Objective： To study the effect of solid dispersion technology and inclusion technology on dissolution performance of Pulsatillae total saponins, and preliminarily investigate its mechanism. Method： The solid dispersion of Pulsatillae total saponins-PEG 4000 was prepared by the melting method. The inclusion compound of Ptdsatillae total saponins-hydroxypropyl-β-eyclodextrin （HP-β- CD） was prepared by the freeze-drying method. The properties of solid dispersion and inclusion compound were identified by using IR, DSC and NMR. And the dissolution of solid dispersion and inclusion compound were also determined by the small glass method. Re- suit： IR, DSC and NMR results showed the formation of solid dispersion and inclusion compound. In terms of the dissolution, the in- clusion compound ranked first, which was followed by solid dispersion and bulk pharmaceutical chemicals. Conclusion： The inclusion technology could significantly increase the dissolution of Pulsatillae total saponins, whereas the solid dispersion showed no notable solu- bilization effect.

关 键 词：白头翁总皂苷 固体分散体 包合物 溶出度 

分 类 号：TQ461[化学工程—制药化工]