线粒体融合分裂与自噬:运动生理研究的新视角  

Mitochondrial fusion/fission and Mitophagy:A New Prospect for Exercise Physiology Research

作　　者：宋超[1,2] 张竞文[1] 姜宁[1] 

机构地区：[1]天津体育学院天津市运动生理与运动医学重点实验室,健康与运动科学系,天津300381 [2]北京体育大学研究生院,北京100084

出　　处：《体育科研》2013年第6期41-44,共4页Sport Science Research

基　　金：国家自然科学基金(31370021和31000523);天津市应用基础与前沿技术研究计划(11JCYBJC13600);天津市科技创新体系创新平台计划专项(10KJPT024)

摘　　要：自噬是广泛存在于真核细胞内的一种溶酶体依赖性的降解途径,它与泛素-蛋白酶体系统共同维持蛋白质及细胞器更新,对于维持细胞的稳态具有重要意义。线粒体作为真核生物最主要的细胞器之一,其代谢更新对于细胞状态有意义深远。作为线粒体更新的主要机制,线粒体自噬的发生逐渐引起关注。关于损伤的线粒体是如何通过自噬途径被移除的,其相关机制仍旧不明了。有研究认为线粒体融合分裂与线粒体自噬的发生关系密切,可能是其调控的关键部分。本文就线粒体自噬与线粒体融合分裂关系的相关研究进展进行了综述。Autophagy is a lysosomal-dependent degradation pathway in eukaryotic cells for degrading and recycling protein and damaged organelles, together with ubiquitin-proteasome systern. It plays an important role in maintaining cell homeostasis. As one of the main organclles of eukaryotes, its metabolic update is significant to the state of cells. As the main mechanism of mitochondrial update, mitophagy has attracted more and more attention. The related mechanism of how the damaged mitochondria are removed through the way of autophagy remains unclear. Related researches deem that mitochondrial fusion/fission is closely linked with mitophagy. This may be the key part of the regulation. This paper focuses on the researches concerning the relations between mitophagy and mitochondrial fission/fusion.

关 键 词：线粒体 自噬 线粒体自噬 线粒体融合分裂 

分 类 号：G804.5[文化科学—运动人体科学]