O-烷基α-(2,4-二氯苯氧乙酰氧基)烃基膦酸钠的合成与除草活性研究  

Synthesis and herbicidal activity of sodium O-alkylα-(substituted phenoxyacetoxy)alkylphosphonate

作　　者：王涛[1] 高玉焦[1] 彭浩[1] 贺红武[1] 

机构地区：[1]华中师范大学化学学院教育部农药与化学生物学重点实验室,武汉430079

出　　处：《华中师范大学学报（自然科学版）》2013年第6期790-793,共4页Journal of Central China Normal University：Natural Sciences

基　　金：国家重点基础研究发展规划项目(2010CB126100);国家自然科学基金项目(21172090)

摘　　要：选择2,4-二氯苯氧乙酸为起始原料,经氯化亚砜氯化后得2,4-二氯苯氧乙酰氯2,与不同取代的α-羟基烃基膦酸酯反应制备关键中间体3,再与碘化钠反应,合成了6个未见文献报道的O-烷基α-(2,4-二氯苯氧乙酰氧基)烃基膦酸钠4.通过1 H NMR,IR和元素分析对所合成的化合物进行了结构表征,其中4f经过MS进一步确证.初步的生物活性测试结果表明:目标化合物具有较高的除草活性,在10μg/g的浓度下,化合物4a^4e对稗草和油菜根的抑制率均达到了90%以上.Six novel O-alkyl α-（2,4-dichlorophenoxyacetoxy） alkylphosphonate 4 were synthesized by the reactions of key intermediate 3 with NaI.The intermediate 3 was prepared by the treatment of α-hydroxyalkylphosphonates with 2,4-dichlorophenoxy-acetyl chlorides 2 which could be easily obtained by the reaction of 2,4-dichlorophenoxy-acetic acids with excess thionyl chloride.The structures of compounds 4 have been confirmed by 1H NMR,IR spectroscopy and elemental analyses,and compound 4f was analyzed by MS.The results of preliminary bioassay showed that most of title compounds possessed significant herbicidal activity.Compounds 4a～4e exhibited more than 90％inhibitory activity against barnyard grass and rape in the rate of 10 μg/g.

关 键 词：合成 2 4-二氯苯氧乙酰氧基 膦酸钠 除草活性 

分 类 号：O626.2[理学—有机化学]