脂蛋白相关磷脂酶A_2与冠心病和2型糖尿病的关系  

Relationship between lipoprotein-associated phospholipase A_2 and coronary heart disease as well as type 2 diabetes mellitus

作　　者：王树峰[1] 杨丽[2] 刘寅[2] 

机构地区：[1]天津医科大学胸科临床学院心内二科,天津300051 [2]天津市胸科医院心内二科,天津300051

出　　处：《天津医科大学学报》2013年第6期456-458,477,共4页Journal of Tianjin Medical University

基　　金：天津市卫生局科技基金资助项目(2011kz63)

摘　　要：目的:探讨脂蛋白相关磷脂酶A2(Lp-PLA2)与冠心病(CHD)和2型糖尿病(T2DM)的关系。方法:入选患者200例,分为4组,CHD组80例,T2DM组20例,CHD+T2DM组60例,对照组(非CHD非T2DM组)40例。检测Lp-PLA2及C反应蛋白(CRP)。采用析因设计方差分析研究Lp-PLA2及CRP与CHD和T2DM的相关性。同时分析CHD合并T2DM患者Lp-PLA2水平与冠脉病变程度的相关性。结果:CHD组、T2DM组、CHD+T2DM组Lp-PLA2及CRP均高于对照组(均P<0.05),且经析因设计方差分析显示CHD和T2DM在CRP及Lp-PLA2升高方面有交互作用(F=7.62,P<0.05;F=9.68,P<0.05)。CHD+T2DM组冠脉Gensini积分大于CHD组(44.15±36.28 vs 60.51±42.58,P=0.020)。CHD组Lp-PLA2水平与Gensini积分呈正相关(r=0.181,P=0.016),CHD+T2DM组Lp-PLA2水平与Gensini积分也呈正相关(r=0.224,P=0.011),且后者相关性更好。结论:CHD和T2DM在CRP及Lp-PLA2升高方面有交互作用;与单纯CHD患者相比,CHD合并T2DM患者Lp-PLA2水平更高,冠脉病变更重。Objective：To explore the relationship between lipoprotein-associated phospholipase A2 （Lp-PLA2） and coronary heart disease （CHD） as well as type 2 diabetes mellitus （T2DM）.Methods：Two hundred patients were enrolled in the study,and were subdivided into four groups.Factorial analysis of variance was used to study the relationships between Lp-PLA2 and CHD as well as T2DM,and the relationships between C-reaction protein （CRP） and CHD as well as T2DM.And the correlation between the level of Lp-PLA2 and the severity of coronary atherosclerosis of patients with CHD and T2DM was calculated.Results：The levels of CRP of CHD group,T2DM group,and CHD＋T2DM group were all higher than those of the control group （all P〈0.05）.So was the level of Lp-PLA2 （all P〈0.05）.Factorial analysis of variance showed CHD and T2DM could interact with CRP and Lp-PLA2 （F=7.62,P〈0.05; F=9.68,P〈0.05）.The Gensini score of CHD＋T2DM group was higher than that of CHD group （44.15±36.28 vs 60.51±42.58,P=0.020）.The level of Lp-PLA2 was positively correlated with the Gensini score in the CHD group （r=0.181,P=0.016）.And so was the levels of Lp-PLA2 in the CHD＋T2DM group （r=0.224,P=0.011）.Conclusion：CHD and T2DM can interact with CRP and Lp-PLA2.Compared with the patients with coronary heart disease alone,the level of Lp-PLA2 is higher and the coronary atherosclerosis is more severe for the patients with coronary heart disease and type 2 diabetes.

关 键 词：脂蛋白相关磷脂酶A2 糖尿病 2型 冠状动脉疾病 GENSINI积分 

分 类 号：R587.2[医药卫生—内分泌]