糖尿病周围神经病的单纤维肌电图研究  

Single fiber electromyography in diabetic peripheral neuropathy

作　　者：卢祖能[1] 王真真[1] 王镇涛[1] 曾庆杏[1] 胡胜 周桂兰 李竞[2] 聂传云[1] 

机构地区：[1]湖北医科大学附属第一医院暨湖北省人民医院神经科，430060 [2]湖北医科大学附属第一医院暨湖北省人民医院

出　　处：《中华物理医学与康复杂志》2000年第6期349-351,共3页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：湖北省科委基金资助项目(972P1212 )

摘　　要：目的　探讨单纤维肌电图 (SFEMG)在糖尿病周围神经病 (DPN )中的应用。方法　Ⅱ型糖尿病患者 36例 ,采用VikingIV肌电图仪 ,测定指总伸肌的颤抖和纤维密度 (FD) ,同时进行常规神经传导检测 (NCS)并测量空腹血糖和糖化血红蛋白 (HbA1C)。结果　颤抖和FD具有相关性 ,且均与HbA1C呈正相关。 18例NCS异常者 ,颤抖值均超出正常范围 (11例伴阻滞 ) ,14例FD增加 ;18例NCS正常者 ,7例颤抖值增大 (3例伴阻滞 ) ,5例FD增加。结论　颤抖和FD所反映的失神经 -神经再支配与代谢状况相关联 ;SFENG是DPN早期诊断的敏感手段 。Objective To study the clinical significance of single fiber electromyography (SFEMG) in diabetic peripheral neuropathy (DPN). Methods Thirty six patients with diabetes mellitus were investigated, in which the values of jitter and fiber density (FD) of m. extensor digitorum common were determined by Viking IV electromyography, meanwhile conventional nerve conduction studies (NCS) were performed, and fasting blood glucose and glycosylated hemoglobin A 1C (HbA 1C ) measured. Results The values of jitter were associated with FD, and both jitter and FD were positively related to HbA1C. Eighteen cases with abnormal NCS showed increased jitter in 18 (with block in 11) and increased FD in 14, the remaining 18 cases with normal NCS showed increased jitter in 7 (with block in 3) and increased FD in 5. Conclusion Denervation reinnervation reflected by jitter and FD was associated with the metabolic status. SFEMG could be served as sensitive means in early diagnosis of DPN, and may detect subclinical neuropathy.

关 键 词：糖尿病周围神经病 单纤维肌电图 诊断 

分 类 号：R587.2[医药卫生—内分泌]