中药促进内皮祖细胞功能治疗血管损伤性疾病的研究进展  

Traditional Chinese medicine promote the function of endothelial progenitor cells in the treatment of diseases of vascular injury

作　　者：贺爽[1] 郭浩[1] 徐砚通[1] 覃刚健[1,2] 高秀梅[1] 朱彦[1] 

机构地区：[1]天津中医药大学,天津300193 [2]美国西北大学,芝加哥60611

出　　处：《中华中医药杂志》2013年第12期3612-3619,共8页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重点基础研究发展计划(973计划)(No.2012CB518400);教育部博导基金(No.20111210110007)~~

摘　　要：在治疗血管损伤性疾病过程中,损伤血管内膜再内皮化及缺血部位血管新生均起到了重要作用,内皮祖细胞(endothelial progenitor cells,EPCs)具有定向参与以上两个过程的作用。查阅近年来国内外具有代表性的文献,对中药复方、中药有效成分促进EPCs功能以达到治疗血管损伤性疾病的实验研究结果进行分析,归纳,很多中药复方及其有效成分被证实具有良好的促进EPCs增殖并改善其功能的作用,如促进EPCs定向迁移,动员EPCs至血管损伤部位进行修复等,但具体作用机制尚需深入研究。Re-endothelialization of damaged endangium and angiogenesis of ischemic parts play an important role in the treatment of vascular injury diseases. Numerous studies have shown that endothelial progenitor cells （EPCs） participate in the two processes directly or indirectly. Bone-marrow derived EPCs are used for the treatment of ischemic diseases in clinical trials and circulating EPC levels are considered as biomarkers for coronary and peripheral artery diseases. Traditional Chinese medicine is a rich source of cardiovascular medicine, particularly those with blood circulation-promoting and blood stasis-removing properties. Chinese herbal formula and their active ingredients active in improving EPCs functions such as proliferation, migration, and angiogenesis are reviewed in this article, but further investigations are required to understand the chemical basis and mechanism of action of these EPC promoting herbal medicine in order to better utilize this natural resource for the development of more effective treatment for ischemic cardiovascular diseases.

关 键 词：中药 内皮祖细胞 血管损伤性疾病 

分 类 号：R259[医药卫生—中西医结合]