芋菇颗粒对S180荷瘤小鼠抑瘤作用的研究  

Experimental study of anti-cancer effects of Yugu Granules on S180 cancer mice

作　　者：朱晓燕[1] 刘加葳[1] 吴洪斌[1] 孟志强[1] 

机构地区：[1]复旦大学附属肿瘤医院,复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中华中医药杂志》2013年第12期3720-3723,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：上海市科委中药现代化专项基金(No.11DZ1971000)~~

摘　　要：目的:观察芋菇颗粒及其不同组分对S180荷瘤小鼠的抑瘤作用,探讨芋菇颗粒可能的有效组分。方法:实验一:采用细胞接种的方法建立S180荷瘤ICR小鼠动物模型,将模型小鼠随机分成6组:模型对照组、组分1治疗组、组分2治疗组、组分3治疗组、组分4治疗组、环磷酰胺组,每组各8只,检测芋菇颗粒不同组分对S180荷瘤小鼠的抑瘤作用。实验二:采用细胞接种的方法建立S180荷瘤ICR小鼠动物模型,将模型小鼠随机分成6组:模型对照组、环磷酰胺组、山慈菇醇提组、芋菇颗粒复方高、中、低剂量组,每组各10只,观测芋菇颗粒复方不同剂量对S180荷瘤小鼠抑瘤作用。结果:研究发现,组分3治疗组对S180荷瘤小鼠的抑瘤率为48.7%(P<0.01),组分4治疗组的抑瘤率为31.0%(P<0.01);山慈菇醇提组的抑瘤率为53.0%(P<0.01),芋菇颗粒复方高剂量组的抑瘤率为33.3%(P<0.05),芋菇颗粒复方中剂量组抑瘤率为22.1%(P<0.05),与模型对照组比较差异均具有统计学意义。结论:山慈菇醇提物、芋菇颗粒复方水提取均对S180荷瘤小鼠的实体瘤有一定的抑制作用,山慈菇醇提部分作用较强,可能是芋菇颗粒的有效成分之一。Objective： Studying the anti-tumor effects of Yugu Granules in S180 cancer mice, in order to explore the active fraction of Yugu Granles. Methods： Experiment 1, after establishing the S180 cancer mice model by cell vaccination, the cancer-beating ICR mice were divided into 6 groups： control group （regular cancer-bearing mice）, Fraction 1 group, Fraction 2 group, Fraction 3 group, Fraction 4 group and Cyclophosphamide group, with 8 cases in each group. The anti-tumor effects of different fractions of Yugu Granules on S 180 cancer mice were studied. Experiment 2, after establishing the S 180 cancer mice model by cell vaccination, the cancer- bearing ICR mice were divided into 6 groups： control group （regular cancer-beating mice）, cyclophosphamide group, Indian iphigenia bulb alcohol extract group, Yugu granules of high dose, middle dose and low dose group, with 10 cases in each group. The anti-tumor effects of different dosages of Yugu Granules on S180 cancer mice were studied. Results： The results showed that the anti-tumor rate of fraction 3 group was 48.7% （P〈0.01）, fraction 4 group was 31.0% （P〈0.01）, Indian iphigenia bulb alcohol extract group was 53.0% （P〈0.01）, Yugu granules of high dose group was 33.3% （P〈0.05）, Yugu Granules of middle dose group was 22.1% （P〈0.05）, there was significant different with control group. Conclusions： Indian iphigenia bulb alcohol extract group, Yugu granules water extract can significantly inhibit the growth of S180 cancer cell in mice. Indian iphigenia bulb alcohol extract group showed a strong part of the role, and it maybe one of the effecfve component fractions of Yugu granules.

关 键 词：芋菇颗粒 S180荷瘤小鼠 抑瘤作用 

分 类 号：R285.5[医药卫生—中药学]