吗啡类药物所致肿瘤患者便秘的中医证候相关性研究  

Correlative Study on TCM Syndrome of Constipation in Tumor Patients Induced by the Administration of Morphine

作　　者：张雅月[1] 刘洋[2] 许亚梅[1] 李忠[1] 陈信义[1] 

机构地区：[1]北京中医药大学东直门医院,北京100007 [2]北京中医药大学,北京100029

出　　处：《中医学报》2013年第12期1789-1791,共3页Acta Chinese Medicine

基　　金：北京中医药大学自主选题项目(编号:2009CB522705)

摘　　要：目的:探讨肿瘤患者因服用吗啡类药物所致便秘与气虚气滞证候的关系,明确吗啡类药物导致便秘的中医病机,为建立肿瘤患者因服用吗啡类药物所致便秘的中医药治疗规范提供循证医学依据。方法:收集61例应用吗啡类药物导致便秘患者,通过统计学软件(SPSS17.0)分析气虚气滞证与排便积分间的相关性与回归性。结果:①Pearson相关系数r=0.956、P=0.000<0.001,提示气虚气滞证患者严重程度与便秘程度呈直线相关;②一元线性回归结果显示在回归方程中,F=632.205,P=0.000<0.001,提示回归方程有统计学意义,即气虚气滞证候积分与排便积分存在一元线性关系。结论:肿瘤患者因服用吗啡类药物所引发的便秘严重程度与其气虚气滞证的严重程度具有高度的相关性,且二者具有一元线性回归关系。Objective： To explore the relationship between constipation in tumor patients induced by the administration of morphine and qi deficiency and stagnation syndrome, so as to clarify TCM pathogenesis of constipation, and providing the basis of evidence-based medi- cine for TCM standard treatment of constipation in tumor patients induced by morphine. Methods ： Collected clinical data about constipa- tion induced by the administration of morphine from 61 tumor patients. Analyzed the correlation and recursion between defecation scores and syndrome scores of qi deficiency and stagnation in Chinese medicine by statistical software （SPSS 17.0）. Resuhs ：①Correlation re- sult showed that the Pearson correlation coefficient r = 0. 956, P = 0. 000 〈 0. 001, which indicated the linear correlation between the symptom of defecation and the syndrome of qi deficiency and stagnation in Chinese medicine;②The result of unary linear regression e- quation showed that F = 632.205, P = 0.000 〈 0.001, which indicated unary linear relationship between the above two factors. Conclu- sion：In the range of this clinical trial, there is high correlation between constipation in tumor patients induced by the administration of morphine and syndrome of qi deficiency and stagnation in Chinese medicine, and there is unary linear regression relationship between the two factors.

关 键 词：肿瘤 便秘 吗啡类药物 气虚气滞证 中医证候 

分 类 号：R273[医药卫生—中西医结合]