复方浙贝颗粒干预难治性急性白血病围化疗期生活质量的研究  

Research on the Life Quality of Refractory Acute Leukemia Patients Intervened by Compound Zhebei Granule during Perichemotherapy

作　　者：王荣华[1] 侯丽[1] 陈信义[1] 李冬云[1] 许亚梅[1] 白桦[1] 于婷婷[1] 

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《中医学报》2013年第12期1892-1894,共3页Acta Chinese Medicine

基　　金：国家科技支撑计划项目(编号:2006BAI04A18)

摘　　要：目的:探讨复方浙贝颗粒对难治性急性白血病围化疗期生活质量的影响。方法:采用随机、双盲、安慰剂对照、多中心临床研究的方法。统一拟定难治性急性白血病围化疗期诊断标准、临床研究方案和病例观察表。设立治疗组118例与对照组117例,使用标准化疗方案,同时于化疗前3 d加用复方浙贝颗粒或模拟剂,每次1袋,每日2次,连续给药14 d。以一个标准化疗疗程为治疗周期,采用卡诺夫斯基(Karnofsky,KPS)评分进行疗效观察。结果:KPS评分两组比较无显著差异(P>0.05),两组治疗前后比较,差异有统计学意义(P<0.05),治疗期间KPS评分呈下降趋势。结论:复方浙贝颗粒联合1个疗程化疗在改善难治性急性白血病患者生活质量方面作用不明显。Objective：To explore and study the impact of Compound Zhebei Granule on the patients＇ quality of life（QOL） who have re- fractory acute leukemia （RAL） during perichemotherapy. Methods ： Firstly, the methods of randomization, double-blind, placebo control and multi-center clinical trial were applied. Unified diagnostic standards, clinical research approach and disease-related tables for refrac- tory acute leukemia patients were studied out. Secondly, standard chemotherapy for the treatment group （ 118 cases）and the control group （117 cases）was applied 3 days before chemotherapy using Compound Zhebei Granule or simulated agents, 1 bag each time, twice a day, 14 days of administration. Finally, with a standard chemotherapy regimen for the treatment course, the efficacy after the treatment by the scores of KPS （karnofsky） was assessed. Results： The difference of KPS between two groups were insignificant （ P 〉 0.05 ） and the difference of that within groups were significant（ P 〈 0.05）. The KPS had a downtrend during the treatment. Conclusion：The effect of Compound Zhebei Granule combined with one course of chemotherapy to improve the QOL of the RAL patients is not obvious.

关 键 词：复方浙贝颗粒 难治性急性白血病 化学疗法 生活质量 

分 类 号：R259.337.1[医药卫生—中西医结合]