呋喃西林溶液的制备方法改进及稳定性评价  

Improvement of Furacillin Solution Preparation and Its Stability Evaluation

作　　者：石嫱[1] 庆格乐[1] 

机构地区：[1]武警内蒙古总队医院药剂科,内蒙古呼和浩特010020

出　　处：《中国药业》2013年第23期45-46,共2页China Pharmaceuticals

摘　　要：目的改进呋喃西林溶液的制备方法并评价其稳定性。方法以呋喃西林为主药,加入氯化钠调节渗透压,以紫外分光光度法测定呋喃西林的含量,采用经典恒温法、自然留样观察试验考察其稳定性。结果其含量的变化属一级降解反应,25℃室温时,分解速率常数k25℃=1.915 6×10-5/h,分解10%的时间为7.64个月;5℃室温保存不产生沉淀和结晶。结论新呋喃西林溶液的有效期为6个月,5℃以上室温保存。Objective To improve the preparation method of furacillin solution and to evaluate its stability. Methods Furacillin was taken as the principal agent and sodium chloride was added for adjusting the osmotic pressure. The furacillin content was determined by UV spectrophotometry. The classical constant temperature method and the natural reserved sample observation were applied to investigate its stability. Results The content change of the furaeillin solution belonged to the first- order degradation reaction. The decomposition rate constant k25℃= 1. 915 6 × 10^-5/h at the room temperature of 25℃. The time for 10% disintegration was 7.64 months. Storage at 5℃ had no precipitation and crystallization. Conclusion The expiration date for the new furacillin solution is set on 6 months for storage at the room temperature above 5℃.

关 键 词：呋喃西林溶液 经典恒温法 自然留样观察试验 稳定性 有效期 

分 类 号：R944.16[医药卫生—药剂学] R979.7[医药卫生—药学]