维持性血液透析患者外周血白细胞计数与颈动脉粥样硬化关系  

Relationship between Peripheral White Blood Cell Count and Carotid Artery Atherosclerosis in Maintenance Hemodialysis Patients

作　　者：潘金林[1] 岳菊三 吴耀俊 王坚[1] 聂黎明[1] 林翼金 

机构地区：[1]江苏省丹阳市人民医院肾内科,212300

出　　处：《中国全科医学》2013年第33期3970-3972,共3页Chinese General Practice

基　　金：丹阳市社会发展项目(DK2011005)

摘　　要：目的 探讨维持性血液透析患者外周血白细胞计数（WBC）及其亚类与颈动脉粥样硬化的关系.方法 选取2010年1月-2013年1月我院血液透析中心资料完整的维持性血液透析患者73例,根据颈动脉超声检查结果分为硬化组和对照组,测定两组患者外周血血红蛋白、WBC及其亚类、血清清蛋白（ALB）、血脂、超敏C反应蛋白（hs-CRP）水平,分析WBC与颈动脉粥样硬化的关系.结果 73例患者有27例（37%）检出颈动脉粥样硬化,硬化组患者WBC、淋巴细胞计数、单核细胞计数、总胆固醇（TC）水平及微炎症状态检出率高于对照组,差异均有统计学意义（P＜0.05）;两组患者血红蛋白、中性粒细胞计数、ALB、三酰甘油（TG）、载脂蛋白A（Apo-A）、载脂蛋白B（Apo-B）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平比较,差异均无统计学意义（P＞0.05）.73例患者WBC为（3.44～9.67）×109/L,根据25%和75%分位数4.85×109/L和6.55×109/L分为低、中、高3组.3组颈动脉粥样硬化检出率比较,差异无统计学意义（P＞0.05）;3组微炎症状态检出率比较,差异有统计学意义（P＜0.05）.结论 WBC增多,尤其是淋巴细胞计数和单核细胞计数升高是维持性血液透析患者颈动脉粥样硬化的相关因素.Objective To study the relationship between peripheral white blood cell count （WBC） and its subtypes with carotid artery atherosclerosis in maintenance hemodialysis （MHD） patients. Methods 73 MHD patients with complete data admitted to our hospital from January 2010 to January 2013 were selected. The patients were divided into atherosclerosis group and control group. The peripheral blood hemoglobin, WBC and its subtypes, ALB, blood lipid and hs - CRP were detected. The rela- tionship of these parameters with carotid artery atherosclerosis was analyzed. Results 27 （37%） out of the 73 cases had carotid atherosclerosis. The WBC, lymphocyte count, monocyte count, TC and incidence of mieroinflammatory status of the atherosclero- sis group were significantly higher than the control group （ P 〈 0. 05 ） . The hemoglobin, neutrophil count, ALB, TG, Apo - A, Apo - B, HDL - C and LDL - C between the two groups showed no statistically significant difference （ P 〉 0. 05 ）. The WBC of the 73 patients was （3.44 -9. 67） ~ 109/L, and the patients were divided into low, middle and high level groups. The detection rate of carotid atherosclerosis among the three groups showed no statistically significant difference （P 〉 0.05 ） . The microinflammatory status among the three groups showed statistically significant difference （ P 〈 0. 05 ）. Conclusion Increased white blood cell count, especially lymphocyte count and monocyte count are the related factors of carotid artery ather- osclerosis in MHD patients.

关 键 词：白细胞计数 肾透析 动脉粥样硬化 

分 类 号：R459.52[医药卫生—治疗学]