Toxicity of superparamagnetic iron oxide nanoparticles: Research strategies and implications for nanomedicine  

作　　者：李蕾 江玲玲 曾云 刘刚 

机构地区：[1]Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University [2]Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College

出　　处：《Chinese Physics B》2013年第12期24-33,共10页中国物理B（英文版）

基　　金：Project supported by the Major State Basic Research Development Program of China(Grant Nos.2013CB733802 and 2014CB744503);the National Natural Science Foundation of China(Grant Nos.81101101 and 51273165);the Key Project of Chinese Ministry of Education(Grant No.212149);the Fundamental Research Funds for the Central Universities,China(Grant Nos.2013121039 and ZK1002)

摘　　要：Superparamagnetic iron oxide nanoparticles （SPIONs） are one of the most versatile and safe nanoparticles in a wide variety of biomedical applications. In the past decades, considerable efforts have been made to investigate the potential adverse biological effects and safety issues associated with SPIONs, which is essential for the development of next-generation SPIONs and for continued progress in translational research. In this mini review, we summarize recent developments in toxicity studies on SPIONs, focusing on the relationship between the physicochemical properties of SPIONs and their induced toxic biological responses for a better toxicological understanding of SPIONs.Superparamagnetic iron oxide nanoparticles （SPIONs） are one of the most versatile and safe nanoparticles in a wide variety of biomedical applications. In the past decades, considerable efforts have been made to investigate the potential adverse biological effects and safety issues associated with SPIONs, which is essential for the development of next-generation SPIONs and for continued progress in translational research. In this mini review, we summarize recent developments in toxicity studies on SPIONs, focusing on the relationship between the physicochemical properties of SPIONs and their induced toxic biological responses for a better toxicological understanding of SPIONs.

关 键 词：superparamagnetic iron oxide nanoparticle nanotoxicity cytotoxicity oxidative stress reactive oxygen species 

分 类 号：O561[理学—原子与分子物理]