瘦素抵抗在妊娠期大绒鼠体重调节中的作用  

Effect of Leptin Resistance on Body Mass in Pregnant Eothenomys Miletus

作　　者：杨盛昌[1] 王政昆[1] 杨晓楠 朱万龙[1] 张浩[1] 章迪[1] 沐远[1] 郑佳[1] 余婷婷[1] 姜文秀[1] 

机构地区：[1]云南师范大学生命科学学院,云南昆明650500 [2]剑川县第一中学,云南剑川671300

出　　处：《云南师范大学学报（自然科学版）》2013年第5期59-63,共5页Journal of Yunnan Normal University:Natural Sciences Edition

基　　金：国家自然科学基金资助项目(31071925;31260097);云南省应用基础研究计划资助项目(2011FZ082)

摘　　要：为探讨大绒鼠妊娠期是否出现瘦素抵抗(Leptin resistance)。测量了野外捕捉的42只成年雌性大绒鼠的体重、脂肪重量和血清瘦素浓度。结果发现,有怀孕鼠8只,体重和血清瘦素浓度显著高于非怀孕鼠34只。血清瘦素浓度与体重和脂肪含量显著正相关。结果表明,妊娠期大绒鼠可能存在瘦素抵抗,允许其体重调节点升高,适应妊娠期能量需求的增加。In order to investigate whether to exist leptin resistance in pregnant Eothenomys miletus,body mass,body fat content and serum leptin levels in the field of female E.miletus （42）were measured in this study.It shown that body mass and serum leptin levels in pregnant voles（8）were higher than that in non-reproductive voles（34）.In addition,serum leptin levels were positively correlated with body mass and body fat content.These results suggested that pregnant voles may exist the phenomenon of leptin resistance which increased body mass set-point to adapt the high energy demands for pregnancy.

关 键 词：瘦素抵抗 能量代价 妊娠期 大绒鼠 

分 类 号：Q955[生物学—动物学]