三光气在L-乳酸-O-羧基内酸酐合成中的应用  

Triphosgene application in the synthesis of L-lactic acid-O-carboxyanhydride

作　　者：夏海东[1] 阚苏立[1] 周锋[1] 崔赛德 吴文卓[1] 李振江[1] 

机构地区：[1]南京工业大学生物与制药工程学院,南京211800

出　　处：《生物加工过程》2013年第6期86-89,共4页Chinese Journal of Bioprocess Engineering

基　　金：国家高技术研究发展计划(863计划)(2011AA02A202)

摘　　要：三光气与L-乳酸锂盐反应,合成L-乳酸-O-羧基内酸酐。反应在四氢呋喃中进行,三光气与乳酸锂的摩尔比为1.2∶1,在65℃下反应45 min,并鼓吹大量惰性气体,可以有效地排除副产物HCl,产率为89%。The use of triphosgene in the synthesis of the L-lactic acid-O-carboxyanhydride was reported. The reaction was carried out in tetrahydrofuran, and the ratio of triphosgene and lithium lactate was 1.2： 1, at the reaction temperature of 65 ℃ the reaction time was 45 min, and the byproduct HCl was removed by large amounts of inert gas. The yield was 89%.

关 键 词：三光气 L-乳酸-O-羧基内酸酐 优化 

分 类 号：TQ225.22[化学工程—有机化工]