锌在人体病理性矿化灶中分布的地球化学讨论  

A geochemical discussion on the distribution of zinc in the pathological mineralization of the human body

作　　者：孟繁露[1] 王长秋[1] 李艳[1] 鲁安怀[1] 梅放[2] 柳剑英[2] 

机构地区：[1]造山带与地壳演化教育部重点实验室北京大学地球与空间科学学院,北京100871 [2]北京大学医学部基础医学院病理学系,北京100083

出　　处：《岩石矿物学杂志》2013年第6期789-796,共8页Acta Petrologica et Mineralogica

基　　金：国家自然科学基金资助项目(41272048,40872196)

摘　　要：Zn是人体必需的微量元素之一,与疾病的发生发展关系密切。目前,Zn在人体病理性矿化灶中的分布尚不明确。本文利用同步辐射X射线荧光分析和成像技术,对乳腺癌、乳腺纤维腺瘤、乳腺增生症、乳腺炎症、卵巢浆液癌、主动脉钙化和冠状动脉钙化等病灶中的矿化物共28例中的元素含量和分布进行了测试分析,发现Zn与Ca在矿化灶中的分布总体一致,部分区域此消彼长,与Sr-Ca关系相似,提示Zn进入(碳)羟磷灰石晶格占据Ca的位置。此外,乳腺癌与乳腺良性病变中矿化灶的Ca/Zn(摩尔浓度)值有显著差异(P<0.01),乳腺癌矿化灶中Zn元素含量较高。As one of the essential trace elements in human bodies,zinc has close relationship with the occurrence and development of diseases.Up till now,the distribution of zinc in pathological mineralization is still obscure.This paper focuses on the mineralization of breast cancer,fibroadenoma of breast,breast hyperplasia,breast inflammation,ovarian serous cancer,aortic calcification and coronary artery calcification,based on 28 cases.After the mineral separation process,the measurement of element content was carried out by using micro-area synchrotron radiation X-ray fluorescence （μ-SRXRF）.μ-SRXRF mapping was also conducted to determine the distribution of zinc and calcium.The distribution of zinc in all the types of diseases studied is generally consistent with that of calcium,but shows opposite trend in some parts,similar to the Sr-Ca relationship.Therefore,Zn might occupy the place of Ca in the crystal lattices of （carbonate） hydroxyapatite.Besides,Ca/Zn （mM concentration） values of the mineralization in breast cancer is significantly different from those in breast benign lesions （P＜ 0.01）,because the concentration of Zn in breast cancer is higher than that of breast benign lesions.

关 键 词：微量元素 同步辐射 乳腺癌 锌 钙化 

分 类 号：P579[天文地球—矿物学]