弱视的功能MRI研究现状与进展  

The research status and advance of functional MRI in amblyopia

作　　者：肖曼君[1] 李亚军[1] 肖恩华[1] 

机构地区：[1]中南大学湘雅二医院放射科,长沙410011

出　　处：《磁共振成像》2013年第6期463-467,共5页Chinese Journal of Magnetic Resonance Imaging

摘　　要：功能MRI(functional magnetic resonance imaging,fMRI)技术可以无侵入、直观地对人体大脑组织进行成像,并且能反应大脑特定区域的功能活动特点,在弱视的研究应用中得到了快速发展。血氧水平依赖MRI(blood oxygen leveldependent functional MRI,BOLD-fMRI)可以分析皮层功能改变与视力损害间的关系,扩散张量成像(diffusion tensor imaging,DTI)提供了常规MRI技术所不能获得的白质图像及神经通路的三维显像。运用多项fMRI技术可以分析正常大脑的灰质、白质的功能特点,进而对弱视患者视觉皮层功能分区、皮层功能损害特点及相应脑白质改变进行研究,为探讨弱视患者初、高级视觉皮层功能损害及脑白质视觉通路联系异常发生的复杂神经病理机制提供思路,为临床诊断、治疗监测及预后提供参考。The fMRI not only can imaginate in human＇s brain tissue but also may reflect the functional activitiy of the certain region intuitively and without invation,so it developed rapidly in the study of the amblyopia. The Bold-fMRI can analyse the relationship between the transform of cortex funtion and visual impairment. DTI had offered the three-dimensional imagination of the brain white matter and neural pathway which the conventional MRI can＇t obtain. We can analyse the functional characteristics of nomal brain grey and white matter with several kinds of fMRI and study the function division of visual cortex,the functional impairment of cortex and the associated white cortex changement.This progress has provided useful mentality of discussing the functional lesion of primary and advanced visual cortex and the complicated neuropathology mechanism of connetion anomaly in visual pathway. This had offered useful reference in clinical diagnosis, treatment monitoring and prognosis.

关 键 词：弱视 大脑皮质 磁共振 

分 类 号：R445.2[医药卫生—影像医学与核医学] R770[医药卫生—诊断学]