西黄滴丸成型工艺优选  

Optimization of Molding Technology for Xihuang Dropping Pills

作　　者：朱晓静[1] 李峰[1] 吴超 丛晓娟 

机构地区：[1]山东中医药大学药学院,济南250355

出　　处：《中国实验方剂学杂志》2013年第24期36-38,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"重大新药创制"科技重大专项(2010ZX09401-302-1-13)

摘　　要：目的： 优选西黄滴丸的成型工艺。方法： 以滴丸的溶散时限、外观质量及丸重差异为综合评价指标，在单因素试验基础上，选取药物与基质的配比、滴制温度、冷却剂温度、滴距为考察因素，采用正交试验优选西黄滴丸的成型工艺。结果： 最佳成型工艺条件为以PEG8000-PEG10000（1：1）为基质，药物-基质（1：1.5），冷却剂为二甲基硅油100，药液温度75℃，冷却剂温度采用梯度冷却方式（上部温度30℃，下部温度0-5℃），滴速20-25滴/min，滴距4 cm。结论： 优选的西黄滴丸成型工艺合理、稳定可行，为西黄滴丸的临床推广提供参考。Objective： To optimize forming technology of Xihuang dropping pills. Method： With dissolved time,appearance quality and weight variation of dropping pills as comprehensive evaluation index,based on single factor tests,orthogonal test was used to optimize molding technology by taking ratio of drug-matrix,dropping temperature,refrigerant temperature and dropping distance as factors. Result： Optimum forming technology conditions of Xihuang dropping pills were as follows：with PEG8000-PEG10000 （1：1） as matrix,ratio of drug and matrix 1：1.5,dimethyl silicone oil 100 as refrigerant,liquid temperature at 75℃,refrigerant temperature with a gradient cooling model（30℃ as upper temperature and 0-5℃ as the lower temperature）,dropping velocity of 20-25 drops per minute,dropping distance 4 cm. Conclusion： This optimized technology of Xihuang dropping pills was feasible and stable,it could provide a reference for clinical practice of Xihuang dropping pills.

关 键 词：西黄滴丸 正交试验 成型工艺 溶散时限 丸重差异 单因素试验 

分 类 号：R283.6[医药卫生—中药学]