奶牛子宫内膜炎化脓隐秘杆菌对β-内酰胺类抗生素耐药性研究  

Study on the drug resistance of Arcanobacterium pyogenes isolated from dairy cow with endometritis against β-lactam antibiotics

作　　者：刘耀川[1,2] 赵刚[2] 赵敬翠[1] 郭文洁[1] 朱竟赫 王建民 刘明春[1] 

机构地区：[1]沈阳农业大学畜牧兽医学院,沈阳110866 [2]辽宁省重大动物疫病应急中心,沈阳110161

出　　处：《黑龙江畜牧兽医》2013年第12期102-104,共3页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目(30972214);辽宁省自然科学基金项目(20082126)

摘　　要：为了研究β-内酰胺类抗生素的耐药情况,试验采用肉汤微量稀释法测定12种β-内酰胺类抗生素对32株奶牛子宫内膜炎化脓隐秘杆菌分离株的最小抑菌浓度(MIC)。结果表明:分离株对头孢噻呋的耐药率最高,为75.0%;对氨苄西林、青霉素、苯唑西林、阿莫西林的耐药率较高,分别为71.9%、68.7%、56.2%、53.1%;对头孢喹喏的耐药率最低,为12.5%。25株分离株耐受3种以上药物,最多耐受8种药物。建议在治疗化脓隐秘杆菌感染性子宫内膜炎时,应根据药敏试验结果合理用药。To study the resistance to β -lactam antibiotics, a broth microdilution method was used to determine the minimum inhibitory concen- tration （MIC） of 12 β -lactam antibiotics against 32 Arcanobacterium pyogenes strains isolated from dairy cow with endometritis. The resuhs showed that 75.0% of isolates were resistant to cefiiofur, showing a highest resistance rate. The higher resistance rates of the isolates were ob- served against ampicillin （71.9%）, penicillin （68.7%）, oxacillin （56.2%） and amoxicillin （53.1%）. The resistance rate of the isolates to cefquinome was 12.5%, showing a lowest resistance rate. 25 isolates were resistant to at least 3 antibiotics, 8 antibiotics at most. It is sug- gested that the drugs should be used rationally based on the results of drug susceptibility testing while treating endometritis caused by Arcanobac- terium pyogenes.

关 键 词：耐药 化脓隐秘杆菌 Β-内酰胺类抗生素 子宫内膜炎 

分 类 号：S859.796[农业科学—临床兽医学]