心律失常与心脏再同步化治疗无反应性的相关性  

Cardiac Arrhythmia and Cardiac Resynchronization Therapy Nonresponse

作　　者：王建灵[1] 苏立[1] 殷跃辉[1] 

机构地区：[1]重庆医科大学附属第二医院心血管内科 重庆市心律失常治疗中心,重庆400010

出　　处：《心血管病学进展》2013年第6期794-798,共5页Advances in Cardiovascular Diseases

摘　　要：虽然基于肾素-血管紧张素-醛固酮抑制剂、β受体阻滞剂的药物治疗使心力衰竭治疗取得了很大进展,但心力衰竭患者的发病率及病死率仍居高不下。心脏再同步化治疗是近年心力衰竭非药物治疗上的重大进展。但是研究表明心脏再同步化治疗后,仍有约30%的心力衰竭患者对心脏再同步化无反应。现综述了心脏再同步化治疗无反应与心律失常之间的关系,并简要讨论对心脏再同步化治疗无反应的可能机制及预防策略。Although pharmacologic therapy, principally based on inhibitors of the renin-angiotensin-aldosterone system and beta-bloc- ker, has substantially improved the prognosis of patients with systolic heart failure （ HF）, the incidence and mortality of HF remains at a highlevel. The cardiac resynchronization therapy （CRT） was a great progress made in the treatment of HF in the past two decades. However, there were approximately 30% of stubborn patients without good response to CRT. This review focused on the links of the CRT nonresponse and the cardiac arrhythmia and briefly described the mechanism underlying. The potential strategy to obviate CRT nonresponse in clinical practice was also been noted simultaneously.

关 键 词：心力衰竭 心脏再同步化治疗 无反应 心律失常 

分 类 号：R541.6[医药卫生—心血管疾病] R541.7[医药卫生—内科学]