心脏钙离子释放通道阿诺碱受体与某些心血管疾病的关系  

Relationship of Cardiac Calcium Ion Release Channels( Ryanodine Receptor 2) with Some Cardiovascular Diseases

作　　者：胡康新[1] 王安[1] 胡佩(综述)[1] 益西巴珍(审校) 

机构地区：[1]南昌市医学科学研究所,江西南昌330001 [2]成都市三医院成都市心血管病研究所,四川成都610031

出　　处：《心血管病学进展》2013年第6期806-811,共6页Advances in Cardiovascular Diseases

摘　　要：心脏钙离子释放通道之一阿诺碱2型受体的研究在近20年已获得巨大的进展。现简要地复习它的功能、调节,它与某些心血管病如心律失常(儿茶酚胺敏感的多形性室性心动过速、致心律失常性右心室心肌病和心房颤动)、心力衰竭、心肌梗死和药源性高血压的关系以及阻滞阿诺碱受体通道药物包括苯并硫氮衍化物和苯二酚。现对心肌梗死分类为心肌钙通道病范畴的见解提出疑问。Research of cardiac calcium ion release channel（RyR2） had obtained great advance in recent 20 years. Function,regula- tion of RyR2 and its relationship with some cardiovascular diseases such as arrhythmia （catecholaminergic polymorphic ventricular tachycardi- a,arrhythmogenic right ventricular cardiomyopathy and atrial fibrillation） ,heart failure,myocardial infarction and drug-induced hypertension and drugs which block RyR2 channel such as JTVS19 and S107 are reviewed in brief in this paper. We question this view that myocardial in- farction should be classificated as category of cardiac calcium ion channelopathy.

关 键 词：心脏钙离子释放通道 心律失常 心力衰竭 心肌梗死 药源性高血压 

分 类 号：R54[医药卫生—心血管疾病]