中性粒细胞与心肌梗死心肌灌注关系的研究进展  

Advances in Research in Connection Between Neutrophil and Myocardial Reperfusion after Acute Myocardial Infarction

作　　者：杨文波[1,2] 黄广勇[1,2] 

机构地区：[1]泰山医学院聊城临床学院 [2]聊城市人民医院心内科,山东聊城252000

出　　处：《心血管病学进展》2013年第6期839-843,共5页Advances in Cardiovascular Diseases

基　　金：山东省医药卫生科技发展计划项目(2013WS 0090)

摘　　要：急性心肌梗死(AMI)再灌注治疗后的心肌灌注不良明显影响AMI预后。中性粒细胞激活、聚集、血小板白细胞聚集体形成以及氧化应激在心肌灌注不良中起了关键性作用,炎症反应可能是心肌微循环灌注不良中一种共有的纽带,抑制中性粒细胞积聚、激活及抑制血小板白细胞聚集体形成可能改善AMI心肌灌注及预后。Suboptimal myocardial reperfusion after reperfusion therapy in acute myocardial infarction （AMI） was associated with poor prognosis. Neutrophil activation, congregation, the formation of platelet-leukocyte complexes and oxidative stress play a key role in impaired myocardial perfusion in AMI. Inflammation may be a common link between epieardial macrovascular and impaired myocardial peffusion. In- hibition neutrophil activation, congregation, the formation of platelet-leukoeyte complexes may improve myocardial reperfusion and prognosis in AMI.

关 键 词：急性心肌梗死 心肌灌注 中性粒细胞 氧化应激 炎症 

分 类 号：R541.4[医药卫生—心血管疾病]