壳聚糖导管的制备及医用探讨  

The tube produced from chitosan and discussion on its clinical use

作　　者：程瑞[1] 李安茂[2] 

机构地区：[1]第四军医大学西京医院肝胆外科,西安710032 [2]西安市第四医院胸外科,西安710004

出　　处：《西安医科大学学报》2000年第6期589-590,共2页Journal of Xi'an Medical University(Chinese)

摘　　要：目的　探求一种利用导管的制备方法 ,研究壳聚糖材料与血液的相容性。方法　首先 ,利用乙酸溶液制备浓度为 3%壳聚糖乙酸水溶胶 ,包被后用NaOH脱下壳聚糖导管。使用壳聚糖导管建立门体静脉分流通道。在未使大鼠肝素化的条件下观测大鼠肠管血液回流状况。结果　壳聚糖导管具有良好的吸水性能 ,吸收水份的壳聚糖导管变软。 8例大鼠肠管静脉血液顺利通过作为门体静脉分流通道的壳聚糖导管 ,术中未出现肠管充血。结论　壳聚糖导管制备容易 。Objective To explore the method of preparing the tube from chitosan and study the biocompatibility between blood and chitosan.Methods 3% chitosan based hydrolgels were produced from acetic acid and chitosan.The needles coated with chitosan were submerged in NaOH aqueous solutions.The tubes of chitosan were taken off from the needle.The portosystemic shunts were created using the tube of chitosan.This model without heparin was observed whether the intestinal congestion developed or not.Results It was shown that the chitosan based tube has blood in 8 rats went back to veinal system.Conclusion It was easy to prepare the tube from chitosan.The tubes have an excellent biocompatibility with blood.

关 键 词：壳聚糖 静脉支架导管 生物高分子材料 

分 类 号：R318.08[医药卫生—生物医学工程] O636.1[医药卫生—基础医学]