传统头颅MR序列阳性与阴性的重症EV71感染临床特征的差异  

Clinical characteristics in conventional MRI-positive and MRI-negative enterovirus 71 encephalitis

作　　者：江东新[1] 农凤秋[1] 桂见军[1] 赖江明[1] 钟柳眉 

机构地区：[1]暨南大学医学院附属东莞医院(东莞市太平人民医院),523905

出　　处：《中国医疗前沿》2013年第19期48-49,共2页China Healthcare Innovation

基　　金：东莞市科技局2010年重点项目(编号:20101051502599)

摘　　要：目的比较传统MRI阳性EV71脑炎与MRI阴性脑炎患者临床特征。方法选取21位传统MRI阴性的EV71患儿与11位MRI阳性的EV71脑炎患儿,所有患儿进行传统的MRI检查(T1WI、T2WI、FLAIR),并根据检查结果将患儿分为MRI阳性组及MRI阴性组,比较两组临床特征。结果 MRI阴性组的临床特征,包括年龄、性别、高热、皮疹、肢体震颤、头痛、呕吐、心率加快、呼吸加快、高血压、意识障碍、肢体无力、眼球运动异常、肺出血、血糖、血白细胞计数、CSF压力、CSF细胞数、CSF总蛋白与MRI阳性组比较,无统计学差异。结论传统MRI阳性的EV71脑炎患儿,并不代表其临床特征更差。为了识别更加严重的EV71脑炎,可能需要行增强MRI或弥散-加权成像的MRI。Objective Clinical characteristics of conventional MRI-positive as compared to MRI-negative enterovirus 71（EV71） encephalitis are not yet known. Methods We studied 21 conventional MRI-negative and 11 MRI-positive patients with enterovirus 71 encephalitis. All patients underwent conventional MRI（including T1WI, T2WI, and FIAIR） cranial scans and were placed into one of two groups according to MRI results, a MRI-positive group or a MRI-negative group. Clinical characteristics were compared between the two groups. Results Clinical characteristics of the MRI-negative group including age, gender, high fever, rash, limb tremor, headache, vomiting, irritability, tachycardia, tachypnea, hypertesion, disturbance of consciousness, limb weakness, eye movement abnormalities, pneumorrhagia, blood glucose, white blood cell count, CSF pressure, CSF cell count, CSF total protein were not significantly different with the MRI-positive group. Conclusions The positive result from conventional MRI scan may not indicate more severity of clinical feature in EV71 encephalitis patients. To identify the severe cases in EV71 encephalitis patients, enhanced MRI scan or diffusion weighted MRI should be utilize.

关 键 词：肠道病毒71 脑炎 核磁共振磁 脑脊液 

分 类 号：R725.1[医药卫生—儿科]