三苯氧胺软膏剂体外透皮释药  

The Percutaneous Release of Tamoxifen Ointments in Vitro

作　　者：周森麟[1] 丁俊杰[1] 丁霞艳 肖现民[1] 

机构地区：[1]上海医科大学儿科医院,上海200032 [2]上海医科大学98级药学,学生上海200032

出　　处：《儿科药学》1999年第3期15-17,共3页Journal of Pediatric Pharmacy

摘　　要：目的:测定1%三苯氧胺(TAM)在3种软膏基质中的体外透皮释放,评价三种软膏基质对主药经皮渗透的影响.方法:以人离体皮肤为渗透释药模型,试验用Franz扩散池,λ=235nm处UV测定.结果:在凡士林(Vaseline),聚乙二醇类(PEG)和聚羧乙烯(Carbopol)三种基质中TAM的渗透系数分别在0,1.0677和1.2769μg/(Cm^2h),在24h和46h时的累积释放量分别为0,31.87μg/cm^2和23.48μg/cm^2及0,54.63μg/cm^2和52.44μg/cm^2.结论:TAM在水溶性软膏基质PEG和Carbopol的渗透及释放都优于凡士林软膏基质.Aim: To determine the percutaneous release of 1 % Tamoxifen (TAM) in different stroma in vitro, and evaluate the factors affecting drug release, the trransdermal permeation of TAM from the stroma was investigated through human skin in vitro. Method: The Franz diffusion cell was applied, and the samples was measured by UV (λ/235nm). Results: In the different stroma of Vaseline, PEG and Carbopol, the permeation coefficient of TAM are 0, 1. 0677 and 1. 2769, respectively. The cumulative amounts of release were 0, 31. 87 and 23. 48μg· cm-2 in 24 h, and 0, 54. 63 and 52. 44μg· cm-2 in 46 h, respectively. Conclusion: Hydrophilic ointment stromas for TAM, such as PEG and Carbopol were better than hydrophobic one in the percutanous release.

关 键 词：三苯氧胺 软膏基质 体外透皮释药 雌激素受体 

分 类 号：R977.12[医药卫生—药品] R944.21[医药卫生—药学]